U2AF2 and RBM4

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid, two hybrid)

		U2AF2	RBM4
Gene Name		U2 small nuclear RNA auxiliary factor 2	RNA binding motif protein 4
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Gene Ontology Annotations	Cellular Component	Prp19 Complex Nucleoplasm Spliceosomal Complex Nuclear Speck	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytoplasmic Stress Granule Nuclear Speck
	Molecular Function	Nucleotide Binding Protein Binding Enzyme Binding Poly(A) RNA Binding C2H2 Zinc Finger Domain Binding	Nucleotide Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Zinc Ion Binding MiRNA Binding Poly(A) RNA Binding Pre-mRNA Intronic Binding Pre-mRNA Intronic Pyrimidine-rich Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Processing MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing Positive Regulation Of RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome	Regulation Of Alternative MRNA Splicing, Via Spliceosome Cap-independent Translational Initiation IRES-dependent Translational Initiation RNA Processing MRNA Processing RNA Splicing Negative Regulation Of Translation Cell Differentiation Negative Regulation Of Translation In Response To Stress Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Translational Initiation Response To Arsenic-containing Substance Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Circadian Regulation Of Translation
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		51 interactors: AES APBB1 ATXN1 BEND7 CCAR1 CHERP CHIC2 CPSF7 DACH1 DDX17 DDX6 DPPA2 DVL2 EPB41 GEMIN2 GLIS2 HLA-DMA HNRNPA0 HNRNPD HNRNPK IL7R KHDRBS1 KHDRBS3 KIAA0907 LURAP1 MAP1B PIN1 POLR2A PRPF3 PRPF40A PUF60 QKI RBFOX2 RBM39 RBM4 SAP30BP SCAF11 SF1 SMAD5 SNRPA SRPK1 SRPK2 SRSF1 SRSF11 SUGP1 TCERG1 THAP1 TOP1 U2AF1 WT1 ZRSR2	29 interactors: AQR CCNA1 CDK2 CXorf56 DDX17 DDX5 DGCR14 DHX9 HNRNPF HNRNPH2 HNRNPH3 HNRNPK HNRNPM HNRNPUL1 LRP2BP PABPC1 PRPF31 PTBP2 RBM10 RBM22 RBM23 RBM42 RBM7 SF1 SF3B4 SMAD5 SNRPC TRIB3 U2AF2
Entrez ID		11338	5936
HPRD ID		01872	03982
Ensembl ID		ENSG00000063244	ENSG00000173933
Uniprot IDs		P26368	Q9BWF3
PDB IDs		1JMT 1O0P 1OPI 1U2F 2G4B 2HZC 2M0G 2U2F 2YH0 2YH1 3VAF 3VAG 3VAH 3VAI 3VAJ 3VAK 3VAL 3VAM 4FXW	2DNQ
Enriched GO Terms of Interacting Partners?		RNA Processing RNA Splicing MRNA Processing MRNA Metabolic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Biosynthetic Process Spliceosomal Complex Assembly Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Biogenesis Cellular Macromolecular Complex Assembly Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Metabolic Process Regulation Of MRNA Processing Termination Of RNA Polymerase II Transcription Regulation Of MRNA Stability Regulation Of RNA Stability Cellular Process DNA-templated Transcription, Termination Regulation Of Translation MRNA 3'-end Processing Positive Regulation Of Macromolecule Biosynthetic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Female Gonad Development Circadian Regulation Of Translation RNA 3'-end Processing	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing RNA Processing MRNA Metabolic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Processing Cellular Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of RNA Splicing Regulation Of Nitrogen Compound Metabolic Process MRNA Splice Site Selection Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Ribonucleoprotein Complex Assembly Spliceosomal Complex Assembly Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway MRNA Cis Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Skeletal Muscle Cell Differentiation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Ribonucleoprotein Complex Biogenesis MRNA Stabilization Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Spliceosomal SnRNP Assembly Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Meiotic Cell Cycle Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression
Tagcloud ?		acceptor accessory advance alters codons corroborated cytidine doi junctions leu missense november novo online publication q157 q157p q157r s34 s34f s34y seq snrnp speckles splice splicing u2af1 uridine	ago2 altogether argonaute2 associates c2c12 cap colocalizes cytoplasm deposited entry granules micro micrornas microtubule mrnas myoblast notably participates potentiates recruit ribonucleoprotein ribonucleoproteins ribosome rnas suppress suppresses transiently translation translocates
Tagcloud (Difference) ?		acceptor accessory advance alters codons corroborated cytidine doi junctions leu missense november novo online publication q157 q157p q157r s34 s34f s34y seq snrnp speckles splice splicing u2af1 uridine	ago2 altogether argonaute2 associates c2c12 cap colocalizes cytoplasm deposited entry granules micro micrornas microtubule mrnas myoblast notably participates potentiates recruit ribonucleoprotein ribonucleoproteins ribosome rnas suppress suppresses transiently translation translocates
Tagcloud (Intersection) ?