CCDC101 and MED4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CCDC101	MED4
Gene Name		coiled-coil domain containing 101	mediator complex subunit 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ada2/Gcn5/Ada3 Transcription Activator Complex SAGA-type Complex	Nucleus Nucleoplasm Membrane Mediator Complex
	Molecular Function	Protein Binding Methylated Histone Binding	RNA Polymerase II Transcription Cofactor Activity Transcription Cofactor Activity Receptor Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone H3 Acetylation Establishment Of Protein Localization To Chromatin	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Inflammatory bowel disease (early onset) ( 19915574)
Protein-Protein Interactions		12 interactors: CCDC102B CCDC158 CLHC1 HIST3H3 KRT13 KRT15 LNX1 MED4 NDC80 RINT1 TADA3 TCF4	36 interactors: AES AMOT AP2M1 ATF7IP C1orf216 CCDC101 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD HAUS1 IFT20 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED13 MED25 MED30 MED9 NDC80 NDE1 PCBD2 PUM2 SDCBP SMARCD1 SMARCE1 SSX3 TNFAIP8 TXLNA USHBP1 WDTC1
Entrez ID		112869	29079
HPRD ID		13996	16145
Ensembl ID		ENSG00000176476	ENSG00000136146
Uniprot IDs		Q96ES7	Q9NPJ6
PDB IDs		3LX7 3ME9 3MEA 3MET 3MEU 3MEV 3MEW
Enriched GO Terms of Interacting Partners?		Intracellular Steroid Hormone Receptor Signaling Pathway Chromosome Organization Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Cell Cycle Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Regulation Of Tubulin Deacetylation Maintenance Of DNA Repeat Elements Transcription Initiation From RNA Polymerase II Promoter Attachment Of Mitotic Spindle Microtubules To Kinetochore	Organelle Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Nucleosome Disassembly Cellular Protein Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Establishment Of Cell Polarity Cellular Localization Cellular Nitrogen Compound Metabolic Process Mitotic Nuclear Division Centrosome Localization Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Establishment Of Mitotic Spindle Orientation Androgen Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Mediator Complex Assembly Opsin Transport Regulation Of Cellular Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Nitrogen Compound Metabolic Process Chromosome Organization Establishment Or Maintenance Of Cell Polarity Chromatin Organization Cell Division Protein Localization Negative Regulation Of Transcription, DNA-templated Movement Of Cell Or Subcellular Component Spindle Localization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Microtubule-based Process Pteridine-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Negative Regulation Of RNA Biosynthetic Process
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