MED4 and C1orf216

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MED4	C1orf216
Gene Name		mediator complex subunit 4	chromosome 1 open reading frame 216
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mediator Complex
	Molecular Function	RNA Polymerase II Transcription Cofactor Activity Transcription Cofactor Activity Receptor Activity Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: AES AMOT AP2M1 ATF7IP C1orf216 CCDC101 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD HAUS1 IFT20 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED13 MED25 MED30 MED9 NDC80 NDE1 PCBD2 PUM2 SDCBP SMARCD1 SMARCE1 SSX3 TNFAIP8 TXLNA USHBP1 WDTC1	28 interactors: AES AMOT CCDC114 CCDC136 CCDC158 CDR2 CEP170P1 GGA1 KRT13 KRT15 KRT31 KRT38 KRT40 LINC00521 MED4 MTUS2 MYRIP NMI NRBF2 NUP62 PSMC6 RALBP1 TPM1 TPM3 TRAF1 TRIM54 USHBP1 ZDHHC17
Entrez ID		29079	127703
HPRD ID		16145	08798
Ensembl ID		ENSG00000136146	ENSG00000142686
Uniprot IDs		Q9NPJ6	Q8TAB5
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cellular Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Nucleosome Disassembly Cellular Protein Localization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Establishment Of Cell Polarity Cellular Localization Cellular Nitrogen Compound Metabolic Process Mitotic Nuclear Division Centrosome Localization Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Establishment Of Mitotic Spindle Orientation Androgen Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Mediator Complex Assembly Opsin Transport Regulation Of Cellular Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Nitrogen Compound Metabolic Process Chromosome Organization Establishment Or Maintenance Of Cell Polarity Chromatin Organization Cell Division Protein Localization Negative Regulation Of Transcription, DNA-templated Movement Of Cell Or Subcellular Component Spindle Localization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Microtubule-based Process Pteridine-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Negative Regulation Of RNA Biosynthetic Process	Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Heart Rate By Epinephrine Actin Filament-based Movement Regulation Of Stress Fiber Assembly Cellular Response To Stimulus Regulation Of Signaling Establishment Of Cell Polarity Involved In Ameboidal Cell Migration
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