ZHX1 and AKR1C3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZHX1	AKR1C3
Gene Name		zinc fingers and homeoboxes 1	aldo-keto reductase family 1, member C3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Intracellular Nucleus Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding Protein Heterodimerization Activity	Retinal Dehydrogenase Activity Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Retinol Dehydrogenase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Phenanthrene 9,10-monooxygenase Activity Dihydrotestosterone 17-beta-dehydrogenase Activity Prostaglandin D2 11-ketoreductase Activity Geranylgeranyl Reductase Activity Ketoreductase Activity Prostaglandin-F Synthase Activity 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity Androsterone Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Testosterone 17-beta-dehydrogenase (NADP+) Activity Ketosteroid Monooxygenase Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Indanol Dehydrogenase Activity Delta4-3-oxosteroid 5beta-reductase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cell Differentiation Negative Regulation Of Transcription, DNA-templated	Protein Import Into Nucleus, Translocation Retinoid Metabolic Process Prostaglandin Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Nutrient Phototransduction, Visible Light Steroid Metabolic Process Positive Regulation Of Cell Proliferation Male Gonad Development Cellular Response To Starvation Positive Regulation Of Cell Death Farnesol Catabolic Process Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Keratinocyte Differentiation Cellular Response To Reactive Oxygen Species Progesterone Metabolic Process Retinal Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Small Molecule Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Oxidation-reduction Process Testosterone Biosynthetic Process Renal Absorption Cellular Response To Cadmium Ion Cellular Response To Calcium Ion Cellular Response To Prostaglandin Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Jasmonic Acid Stimulus Cellular Response To Prostaglandin D Stimulus Negative Regulation Of Retinoic Acid Biosynthetic Process Regulation Of Testosterone Biosynthetic Process Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Synthesis of bile acids and bile salts via 24-hydroxycholesterol Bile acid and bile salt metabolism Metabolism of lipids and lipoproteins Signaling by Retinoic Acid Diseases associated with visual transduction Arachidonic acid metabolism Synthesis of bile acids and bile salts via 27-hydroxycholesterol Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Visual phototransduction Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Synthesis of bile acids and bile salts RA biosynthesis pathway Retinoid metabolism and transport
Drugs			NADH Bimatoprost 4-Androstenedione Rutin (5e,13e)-9,15-Dihydroxy-11-Oxoprosta-5,13-Dien-1-Oicacid Flufenamic Acid 2\'-Monophosphoadenosine 5\'-Diphosphoribose 3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2\'(5\',5\'-DIMETHYL-6\'OXO)TETRAHYDROPYRAN
Diseases
GWAS
Protein-Protein Interactions		50 interactors: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UTP3 VIM WDR33 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX	5 interactors: ACIN1 LRIF1 MAGEA11 UBE2W ZHX1
Entrez ID		11244	8644
HPRD ID		10379	04911
Ensembl ID		ENSG00000165156	ENSG00000196139
Uniprot IDs		Q9UKY1	B4DKT3 P42330 S4R3Z2
PDB IDs		2ECB 2GHF 2LY9 3NAR	1RY0 1RY8 1S1P 1S1R 1S2A 1S2C 1XF0 1ZQ5 2F38 2FGB 3R43 3R58 3R6I 3R7M 3R8G 3R8H 3R94 3UFY 3UG8 3UGR 3UWE 4DBS 4DBU 4DBW 4DZ5 4FA3 4FAL 4FAM 4H7C
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Viral Process Regulation Of Mitochondrion Organization Negative Regulation Of Biosynthetic Process Apoptotic Process RNA Metabolic Process Programmed Cell Death Cell Death Death Cellular Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription, DNA-templated Negative Regulation Of Gene Expression Cell Cycle Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Rhythmic Process Negative Regulation Of Cell Cycle Developmental Process Positive Regulation Of Protein Metabolic Process Biosynthetic Process Positive Regulation Of Protein Catabolic Process Cell Cycle Process Regulation Of Cell Cycle Process Regulation Of Proteolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Cellular Process Negative Regulation Of Transcription, DNA-templated	Apoptotic Chromosome Condensation Positive Regulation Of Monocyte Differentiation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Monocyte Differentiation Cellular Response To Misfolded Protein Misfolded Or Incompletely Synthesized Protein Catabolic Process Response To Misfolded Protein Negative Regulation Of MRNA Splicing, Via Spliceosome Nitrogen Compound Metabolic Process Negative Regulation Of RNA Splicing Protein K11-linked Ubiquitination Apoptotic Nuclear Changes Protein Monoubiquitination
Tagcloud ?		199a 3p accumulating bound carcinogenesis direct dramatically epigenetic fingers gastric gc homeoboxes inversely involve micrornas mir mirnas n87 nci oncogenic regulator regulators restoring sgc suppressed untranslated upregulated utr zinc	20mug 5alpha abiraterone adrenal afforded androgen androgens androstanedione androstene armamentarium castration claim combinatorial dehydroepiandrosterone delta4 depot dhea dht dihydrotestosterone dione gonadal immunotherapies intratumoral ketoconazole mcrpc p450c17 persists prostatectomy taps
Tagcloud (Difference) ?		199a 3p accumulating bound carcinogenesis direct dramatically epigenetic fingers gastric gc homeoboxes inversely involve micrornas mir mirnas n87 nci oncogenic regulator regulators restoring sgc suppressed untranslated upregulated utr zinc	20mug 5alpha abiraterone adrenal afforded androgen androgens androstanedione androstene armamentarium castration claim combinatorial dehydroepiandrosterone delta4 depot dhea dht dihydrotestosterone dione gonadal immunotherapies intratumoral ketoconazole mcrpc p450c17 persists prostatectomy taps
Tagcloud (Intersection) ?