ZHX1 and EFNA2

Number of citations of the paper that reports this interaction (PMID 12659632)
9

Data Source:
BioGRID (two hybrid)

		ZHX1	EFNA2
Gene Name		zinc fingers and homeoboxes 1	ephrin-A2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Extracellular Region Plasma Membrane Anchored Component Of Membrane Neuromuscular Junction Perikaryon
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding Protein Heterodimerization Activity	Ephrin Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cell Differentiation Negative Regulation Of Transcription, DNA-templated	Cell-cell Signaling Axon Guidance Olfactory Bulb Development Osteoclast Differentiation Bone Remodeling Ephrin Receptor Signaling Pathway
Pathways			EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		50 interactors: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UTP3 VIM WDR33 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX	6 interactors: ADAM10 EPHA2 EPHA3 EPHA5 RUNX1 ZHX1
Entrez ID		11244	1943
HPRD ID		10379	04132
Ensembl ID		ENSG00000165156	ENSG00000099617
Uniprot IDs		Q9UKY1	O43921
PDB IDs		2ECB 2GHF 2LY9 3NAR	2WO3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Viral Process Regulation Of Mitochondrion Organization Negative Regulation Of Biosynthetic Process Apoptotic Process RNA Metabolic Process Programmed Cell Death Cell Death Death Cellular Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription, DNA-templated Negative Regulation Of Gene Expression Cell Cycle Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Rhythmic Process Negative Regulation Of Cell Cycle Developmental Process Positive Regulation Of Protein Metabolic Process Biosynthetic Process Positive Regulation Of Protein Catabolic Process Cell Cycle Process Regulation Of Cell Cycle Process Regulation Of Proteolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Cellular Process Negative Regulation Of Transcription, DNA-templated	Ephrin Receptor Signaling Pathway Neuron Development Axon Guidance Neuron Differentiation Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Generation Of Neurons Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Neurogenesis Cell Morphogenesis Involved In Differentiation Cell Development Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Rho GTPase Activity Peptidyl-tyrosine Phosphorylation Nervous System Development Regulation Of Rho Protein Signal Transduction Cell Morphogenesis Anatomical Structure Morphogenesis Cell Projection Organization Locomotion Protein Phosphorylation Developmental Process Movement Of Cell Or Subcellular Component Regulation Of Ras GTPase Activity Notochord Cell Development Constitutive Protein Ectodomain Proteolysis Regulation Of Cell Adhesion Regulation Of Ras Protein Signal Transduction Response To External Stimulus Positive Regulation Of Progesterone Secretion Phosphorylation Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Organization Regulation Of GTPase Activity Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching PMA-inducible Membrane Protein Ectodomain Proteolysis Axial Mesoderm Formation Regulation Of Progesterone Secretion System Development Regulation Of Hair Follicle Cell Proliferation Peptidyl-amino Acid Modification Notochord Formation
Tagcloud ?		199a 3p accumulating bound carcinogenesis direct dramatically epigenetic fingers gastric gc homeoboxes inversely involve micrornas mir mirnas n87 nci oncogenic regulator regulators restoring sgc suppressed untranslated upregulated utr zinc	16p13 16q12 19p13 21q21 affymetrix agar arrays cd133 cd133high cd133low colonies die extracranial gains genotyping heterozygosity il2rgammac initiating injections lethal nb neurosphere neurospheres orthotopic persist relapses soft tics uncontrolled
Tagcloud (Difference) ?		199a 3p accumulating bound carcinogenesis direct dramatically epigenetic fingers gastric gc homeoboxes inversely involve micrornas mir mirnas n87 nci oncogenic regulator regulators restoring sgc suppressed untranslated upregulated utr zinc	16p13 16q12 19p13 21q21 affymetrix agar arrays cd133 cd133high cd133low colonies die extracranial gains genotyping heterozygosity il2rgammac initiating injections lethal nb neurosphere neurospheres orthotopic persist relapses soft tics uncontrolled
Tagcloud (Intersection) ?