CHN1 and MAPK8IP2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CHN1	MAPK8IP2
Gene Name		chimerin 1	mitogen-activated protein kinase 8 interacting protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Cytoplasm Neuronal Cell Body Protein Complex Neuronal Postsynaptic Density
	Molecular Function	SH3/SH2 Adaptor Activity GTPase Activator Activity Metal Ion Binding Ephrin Receptor Binding	Beta-amyloid Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding Kinesin Binding Protein Kinase Binding Protein Kinase Activator Activity Protein Complex Binding
	Biological Process	Small GTPase Mediated Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Signal Transduction Regulation Of Rac GTPase Activity Positive Regulation Of GTPase Activity Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction	MAPK Cascade Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Regulation Of Receptor Activity Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Positive Regulation Of Protein Kinase Activity Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways		Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ACVR1 BMPR1B CDK5 CDK5R1 ERBB2 GTF3C1 HEMK1 MAPK8IP2 NCK2 RAC1 RPS3A TGFBR1	52 interactors: ADRB2 AFG3L2 APP ASRGL1 BBS10 C14orf1 CFL1 CHN1 CRMP1 DUSP16 EGFR ERBB2 EZH2 FGF12 FSCN1 GBP2 ITSN1 KIFC2 KLC1 LRP1 LRP2 LRP8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 NDUFS6 PLXNA3 PRSS23 RAI1 RBX1 RPS6KB2 SMARCB1 SMS SYNE2 TIAM1 TP53BP2 UNC119 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF784
Entrez ID		1123	23542
HPRD ID		00319	09674
Ensembl ID		ENSG00000128656	ENSG00000008735
Uniprot IDs		P15882	Q13387
PDB IDs		2OSA 3CXL
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Peptidyl-threonine Phosphorylation Regulation Of Protein Phosphorylation Neuron Projection Morphogenesis Neuron Differentiation Axon Guidance Positive Regulation Of Protein Phosphorylation Cell Development Locomotion Regulation Of Kinase Activity Regulation Of Phosphorylation Neuron Projection Development Cell Projection Morphogenesis Positive Regulation Of Phosphorylation Cell Part Morphogenesis Positive Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Axonogenesis Neuron Development Generation Of Neurons Positive Regulation Of Transferase Activity Signal Transduction By Phosphorylation Axon Development Cell Differentiation Anatomical Structure Morphogenesis Chemotaxis Neurogenesis Positive Regulation Of Cellular Protein Metabolic Process Cell Projection Organization Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Cell Migration Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Protein Kinase Activity Serine Phosphorylation Of STAT3 Protein Cell Motility Nervous System Development Regulation Of Cell Death Serine Phosphorylation Of STAT Protein Regulation Of Cell Differentiation	Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade JNK Cascade Signal Transduction By Phosphorylation MAPK Cascade Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity JUN Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of MAP Kinase Activity Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Regulation Of Signal Transduction Response To Light Stimulus Response To External Stimulus Response To Radiation Regulation Of Signaling Intracellular Signal Transduction Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Axon Guidance Regulation Of Intracellular Signal Transduction Signal Transduction Axonogenesis Phosphorylation Cell Part Morphogenesis Axon Development Response To Stimulus Cell Morphogenesis Involved In Neuron Differentiation Response To Abiotic Stimulus Protein Phosphorylation Cellular Response To Stress Signaling
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