COPS6 and MAPKAPK3

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		COPS6	MAPKAPK3
Gene Name		COP9 signalosome subunit 6	mitogen-activated protein kinase-activated protein kinase 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm COP9 Signalosome Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding
	Biological Process	Cullin Deneddylation Viral Process	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Response To Stress Signal Transduction Ras Protein Signal Transduction Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Macropinocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade
Pathways			Signalling to ERKs Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence VEGFA-VEGFR2 Pathway Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade p38MAPK events MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System activated TAK1 mediates p38 MAPK activation Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by VEGF Oxidative Stress Induced Senescence Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade
Drugs
Diseases
GWAS
Protein-Protein Interactions		84 interactors: ANXA1 ANXA7 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS8 COX17 COX5A CRELD1 CUL1 CUL5 DIS3L2 DLEU1 EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 JUN LAMA4 LPL MAP7D1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SLC2A1 SMN1 SNRPG STK40 STX5 SULT1E1 TDGF1 TK1 TP53 TP63 TRDMT1 TRIB3 VIM WIPI2 ZEB2 ZNF24	16 interactors: APP COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM MAPK11 MAPK13 MAPK14 NEDD4 NEDD4L RAB2A SMS SUMO3 TCF3
Entrez ID		10980	7867
HPRD ID		16735	03678
Ensembl ID		ENSG00000168090	ENSG00000114738
Uniprot IDs		Q7L5N1	Q16644
PDB IDs			3FHR 3FXW 3R1N 3SHE
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Developmental Process Intrinsic Apoptotic Signaling Pathway Cellular Metabolic Process Anatomical Structure Development Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Apoptotic Process Regulation Of Catalytic Activity Tissue Development Mitotic Cell Cycle Programmed Cell Death Apoptotic Signaling Pathway Response To Stress Cell Death Catabolic Process Death Regulation Of Cell Proliferation Mitotic Cell Cycle Process Cellular Response To Stress Response To Abiotic Stimulus G1/S Transition Of Mitotic Cell Cycle Regulation Of Apoptotic Process Regulation Of Phosphorylation Response To Organic Cyclic Compound Cell Cycle Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Cell Cycle Phase Transition Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Cycle Organ Development Multicellular Organismal Development Epithelium Development Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Death Response To Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Programmed Cell Death System Development Negative Regulation Of Cell Death Cellular Macromolecule Catabolic Process Response To Organic Substance Regulation Of Protein Kinase Activity Positive Regulation Of Cell Death	Positive Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Regulation Of Muscle Cell Differentiation Posttranscriptional Regulation Of Gene Expression Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Gene Expression Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Protein Metabolic Process Peptidyl-amino Acid Modification Negative Regulation Of Sodium Ion Transport Positive Regulation Of Muscle Cell Differentiation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Regulation Of Protein Kinase Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Response To Organic Substance Response To Stress Regulation Of Kinase Activity Regulation Of Phosphorylation Skeletal Muscle Tissue Regeneration Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Immune System Process Platelet Activation Regulation Of Potassium Ion Transmembrane Transport Regulation Of Gene Expression Protein Monoubiquitination Regulation Of Cell Differentiation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Neurotrophin Signaling Pathway MAPK Cascade
Tagcloud ?		aiming aip alignment boar brms1 chordc1 clues csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h	ca1 ca3 carries corresponds dentate depolarization differential display forskolin frame gyrus identical intron kainic library message mitogen ortholog pc12 pheochromocytoma preceded predicted proline rat reading repressed seizures terminus
Tagcloud (Difference) ?		aiming aip alignment boar brms1 chordc1 clues csde1 csfv ddx5 domestic fever gnb2l1 hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h	ca1 ca3 carries corresponds dentate depolarization differential display forskolin frame gyrus identical intron kainic library message mitogen ortholog pc12 pheochromocytoma preceded predicted proline rat reading repressed seizures terminus
Tagcloud (Intersection) ?