YWHAQ and PIK3C3

Number of citations of the paper that reports this interaction (PMID 7479742)
25

Data Source:
BioGRID (pull down)

		YWHAQ	PIK3C3
Gene Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta	phosphatidylinositol 3-kinase, catalytic subunit type 3
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Membrane Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome	Late Endosome Cytosol Axoneme Phosphatidylinositol 3-kinase Complex Membrane Midbody Phagocytic Vesicle
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein N-terminus Binding	Protein Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity
	Biological Process	Protein Targeting Apoptotic Process Small GTPase Mediated Signal Transduction Substantia Nigra Development Negative Regulation Of Transcription, DNA-templated Membrane Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Autophagic Vacuole Assembly Cytokinesis Toll-like Receptor Signaling Pathway Protein Phosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endosome Organization Insulin Receptor Signaling Pathway Protein Processing Toll-like Receptor 9 Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Response To Leucine Small Molecule Metabolic Process Early Endosome To Late Endosome Transport Innate Immune Response Phosphatidylinositol Phosphorylation Phosphatidylinositol-mediated Signaling Regulation Of Protein Secretion
Pathways		Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis	Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the Golgi membrane Insulin receptor signalling cascade Metabolism of lipids and lipoproteins IRS-mediated signalling IRS-related events IGF1R signaling cascade Synthesis of PIPs at the late endosome membrane IRS-related events triggered by IGF1R Toll-Like Receptors Cascades IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Toll Like Receptor 9 (TLR9) Cascade Phospholipid metabolism PI3K Cascade PI3K Cascade Innate Immune System PI Metabolism Signaling by Insulin receptor
Drugs
Diseases
GWAS		Heart rate variability traits ( 22174390)	Blood trace element (Zn levels) ( 23720494) Obesity-related traits ( 23251661)
Protein-Protein Interactions		231 interactors: AARS2 ABL1 ACSL4 AHCY AKT1S1 ANXA1 ANXA2 APC AR ARHGAP10 ARHGEF16 ATP5A1 BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDK17 CDK18 CDKN1A CDKN1B CEP170 CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 EXO1 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1L1 HADHA HAT1 HAX1 HDAC4 HDAC5 HDAC7 HIST1H2BG HIST2H4A HNRNPA1 HNRNPC HNRNPF HNRNPH1 HNRNPK HSPA1A HSPA8 HUS1 IARS2 ING1 IQGAP1 IRS2 ITGB4 KCNK15 KCNK3 KCNK9 KIAA1429 KIF1C KIF23 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LMO7 LYST MAGOH MAP3K3 MAP3K5 MARK2 MARK3 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPC4 PABPN1 PAK4 PANK1 PCM1 PDCD6 PDE3A PDE3B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C2B PIK3C3 PIK3CB PKM PPFIBP1 PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 PTPN3 RAF1 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SPR SPTA1 SPTB SRSF3 SSBP1 SSFA2 SSX2IP TCP1 TERT THRA TLN1 TNF TNFAIP3 TP53BP2 TPI1 TPR TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS WDR61 WDR77 WEE1 WTAP WWC2 WWP1 YAP1 YWHAE YWHAG ZC3H13 ZHX2	6 interactors: CALM1 PIK3R4 PITPNA SUMO1 YWHAG YWHAQ
Entrez ID		10971	5289
HPRD ID		00886	04009
Ensembl ID		ENSG00000134308
Uniprot IDs		B4DMT8 P27348	A8MYT4 Q8NEB9
PDB IDs		2BTP	3IHY 3LS8
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Organelle Organization Cellular Process Cellular Response To Organic Substance Regulation Of Cellular Component Organization Response To Organic Substance Response To Stimulus Positive Regulation Of Cellular Metabolic Process Developmental Process Positive Regulation Of Metabolic Process Regulation Of Cell Death Mitotic Cell Cycle Regulation Of Metabolic Process Response To Stress Cell Cycle Cellular Response To Stimulus Mitotic Cell Cycle Process Death Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Protein Localization Intracellular Signal Transduction Apoptotic Process Cell Cycle Process Anatomical Structure Development Cell Death Regulation Of Cellular Localization System Development Multicellular Organismal Development Regulation Of Establishment Of Protein Localization Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Protein Metabolic Process Intracellular Transport Regulation Of Signaling Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Regulation Of Phosphorylation Innate Immune Response MRNA Metabolic Process Cellular Localization Immune System Process Regulation Of Kinase Activity	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Membrane Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Substantia Nigra Development Cellular Localization Neural Nucleus Development Positive Regulation Of Mitochondrion Organization Protein Targeting Regulation Of Intracellular Transport Cellular Protein Localization Midbrain Development Regulation Of Mitochondrion Organization Cellular Response To Organic Substance Positive Regulation Of Transport Protein Localization Establishment Of Localization In Cell Regulation Of Protein Localization Innate Immune Response Peroxisome Degradation Response To Organonitrogen Compound Negative Regulation Of Cellular Metabolic Process Regulation Of Immune Response Intrinsic Apoptotic Signaling Pathway PML Body Organization Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Apoptotic Signaling Pathway Intracellular Protein Transport Nervous System Development Response To Hormone Cellular Response To Insulin Stimulus Regulation Of High Voltage-gated Calcium Channel Activity Protein Localization To Nuclear Pore Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Intracellular Transport Regulation Of Cellular Localization Regulation Of Innate Immune Response Response To Organic Substance Protein Localization To Nuclear Envelope Late Endosome To Vacuole Transport Response To Stimulus Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Anatomical Structure Development Transport Response To Insulin Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Protein Phosphorylation Signal Transduction
Tagcloud ?			autophagosome autophagy cdtb coregulators cyld cytolethal deltas destroys distending distension enterica esr1 functionality imported internalized javiana lc3 macrophages nontyphoidal nts salmonella serovar serovars spread toxin typhi typhimurium vacuolization wt
Tagcloud (Difference) ?			autophagosome autophagy cdtb coregulators cyld cytolethal deltas destroys distending distension enterica esr1 functionality imported internalized javiana lc3 macrophages nontyphoidal nts salmonella serovar serovars spread toxin typhi typhimurium vacuolization wt
Tagcloud (Intersection) ?