YWHAQ and TRIM28

Number of citations of the paper that reports this interaction (PMID 15161933)
63

Data Source:
BioGRID (pull down)

		YWHAQ	TRIM28
Gene Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta	tripartite motif containing 28
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Membrane Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nuclear Euchromatin Nuclear Heterochromatin RNA Polymerase II Transcription Factor Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein N-terminus Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Sequence-specific DNA Binding Poly(A) RNA Binding Chromo Shadow Domain Binding
	Biological Process	Protein Targeting Apoptotic Process Small GTPase Mediated Signal Transduction Substantia Nigra Development Negative Regulation Of Transcription, DNA-templated Membrane Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Epithelial To Mesenchymal Transition DNA Repair Transcription Initiation From RNA Polymerase II Promoter Embryo Implantation Gene Expression Protein Ubiquitination Protein Sumoylation Positive Regulation Of Transcription Factor Import Into Nucleus DNA Methylation Involved In Embryo Development Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Oligomerization Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Negative Regulation Of DNA Demethylation Negative Regulation Of Viral Release From Host Cell Regulation Of Genetic Imprinting
Pathways		Activation of BAD and translocation to mitochondria Programmed Cell Death Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Intrinsic Pathway for Apoptosis	Generic Transcription Pathway
Drugs
Diseases
GWAS		Heart rate variability traits ( 22174390)
Protein-Protein Interactions		231 interactors: AARS2 ABL1 ACSL4 AHCY AKT1S1 ANXA1 ANXA2 APC AR ARHGAP10 ARHGEF16 ATP5A1 BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDK17 CDK18 CDKN1A CDKN1B CEP170 CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 EXO1 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1L1 HADHA HAT1 HAX1 HDAC4 HDAC5 HDAC7 HIST1H2BG HIST2H4A HNRNPA1 HNRNPC HNRNPF HNRNPH1 HNRNPK HSPA1A HSPA8 HUS1 IARS2 ING1 IQGAP1 IRS2 ITGB4 KCNK15 KCNK3 KCNK9 KIAA1429 KIF1C KIF23 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LMO7 LYST MAGOH MAP3K3 MAP3K5 MARK2 MARK3 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPC4 PABPN1 PAK4 PANK1 PCM1 PDCD6 PDE3A PDE3B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C2B PIK3C3 PIK3CB PKM PPFIBP1 PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 PTPN3 RAF1 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SPR SPTA1 SPTB SRSF3 SSBP1 SSFA2 SSX2IP TCP1 TERT THRA TLN1 TNF TNFAIP3 TP53BP2 TPI1 TPR TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS WDR61 WDR77 WEE1 WTAP WWC2 WWP1 YAP1 YWHAE YWHAG ZC3H13 ZHX2	62 interactors: CBX1 CBX3 CBX5 CDC34 CDCA4 CEBPB CHAF1A CHD3 ESR1 FES HDAC10 HTRA2 IRF1 IRF7 LYN MAGEA2 MAGEA2B MAGEA3 MAGEA6 MAGED1 MYB NDNL2 NR3C1 NR4A1 NR4A3 PFDN5 PPP4C RNF4 SENP7 SERTAD1 SERTAD2 SETDB1 SIN3A SKI SMARCAD1 SPG7 STAT3 TRIM24 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2N UBE2U VHL VIM YWHAQ ZNF10 ZNF133 ZNF140 ZNF197 ZNF354A ZNF382 ZNF420 ZNF496 ZNF689 ZNF74
Entrez ID		10971	10155
HPRD ID		00886	03445
Ensembl ID		ENSG00000134308	ENSG00000130726
Uniprot IDs		B4DMT8 P27348	Q13263
PDB IDs		2BTP	1FP0 2RO1 2YVR
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Organelle Organization Cellular Process Cellular Response To Organic Substance Regulation Of Cellular Component Organization Response To Organic Substance Response To Stimulus Positive Regulation Of Cellular Metabolic Process Developmental Process Positive Regulation Of Metabolic Process Regulation Of Cell Death Mitotic Cell Cycle Regulation Of Metabolic Process Response To Stress Cell Cycle Cellular Response To Stimulus Mitotic Cell Cycle Process Death Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Protein Localization Intracellular Signal Transduction Apoptotic Process Cell Cycle Process Anatomical Structure Development Cell Death Regulation Of Cellular Localization System Development Multicellular Organismal Development Regulation Of Establishment Of Protein Localization Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Abiotic Stimulus Positive Regulation Of Protein Metabolic Process Intracellular Transport Regulation Of Signaling Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Regulation Of Phosphorylation Innate Immune Response MRNA Metabolic Process Cellular Localization Immune System Process Regulation Of Kinase Activity	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Protein K48-linked Ubiquitination RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Protein Polyubiquitination Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Protein Catabolic Process Cellular Metabolic Process Regulation Of Cellular Process Cellular Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Ubiquitination Biosynthetic Process Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?			accumulates aging becoming damaged depletion genomes il6 il8 ink4a insults kap1 knocked krab limits mediating mixture ois oncogene partially pathologies prevented profound reinforcing sasp secrete secretory senescence termed undergo
Tagcloud (Difference) ?			accumulates aging becoming damaged depletion genomes il6 il8 ink4a insults kap1 knocked krab limits mediating mixture ois oncogene partially pathologies prevented profound reinforcing sasp secrete secretory senescence termed undergo
Tagcloud (Intersection) ?