CFL1 and SSH2

Number of citations of the paper that reports this interaction (PMID 11832213)
123

Data Source:
HPRD (in vivo)

		CFL1	SSH2
Gene Name		cofilin 1 (non-muscle)	slingshot protein phosphatase 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cell-cell Junction Focal Adhesion Membrane Nuclear Matrix Cortical Actin Cytoskeleton Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Vesicular Exosome	Extracellular Space Cytoplasm Cytoskeleton
	Molecular Function	Actin Binding Protein Binding	DNA Binding Actin Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Mitotic Cytokinesis Neural Crest Cell Migration Neural Fold Formation Platelet Degranulation Protein Phosphorylation Protein Import Into Nucleus Cytoskeleton Organization Rho Protein Signal Transduction Axon Guidance Blood Coagulation Response To Virus Regulation Of Cell Morphogenesis Establishment Of Cell Polarity Actin Cytoskeleton Organization Actin Filament Depolymerization Platelet Activation Positive Regulation Of Actin Filament Depolymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Apoptotic Process Response To Amino Acid Innate Immune Response Negative Regulation Of Cell Size Ephrin Receptor Signaling Pathway Regulation Of Dendritic Spine Morphogenesis	Protein Dephosphorylation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Lamellipodium Assembly Actin Cytoskeleton Organization Peptidyl-tyrosine Dephosphorylation Regulation Of Axonogenesis
Pathways		Axon guidance Semaphorin interactions Platelet degranulation EPHB-mediated forward signaling Response to elevated platelet cytosolic Ca2+ Sema3A PAK dependent Axon repulsion EPH-Ephrin signaling Platelet activation, signaling and aggregation Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Breast cancer ( 23535729) DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		37 interactors: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CFL2 CLCN5 EGFR HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP NRK POT1 PSEN1 RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 UCHL5 WDR1 YWHAG YWHAQ YWHAZ	2 interactors: ACTB CFL1
Entrez ID		1072	85464
HPRD ID		03261	09487
Ensembl ID		ENSG00000172757	ENSG00000141298
Uniprot IDs		P23528	B4DK64 F5H527 Q76I76
PDB IDs		1Q8G 1Q8X 3J0S 4BEX	2NT2
Enriched GO Terms of Interacting Partners?		Generation Of Neurons Neurogenesis Developmental Process Nervous System Development System Development Multicellular Organismal Development Phosphate-containing Compound Metabolic Process Regulation Of Organelle Organization Cell Differentiation Positive Regulation Of Organelle Organization Anatomical Structure Development Actin Cytoskeleton Organization Cellular Component Assembly Actin Filament-based Process Immune Response-regulating Signaling Pathway Platelet Activation Actomyosin Structure Organization Regulation Of Neurogenesis Anatomical Structure Morphogenesis MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Neuron Differentiation Cell Development Response To Stimulus Axon Guidance Phosphorylation Negative Regulation Of Catalytic Activity Cell Morphogenesis Involved In Neuron Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cellular Component Organization Fc Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Stress Homeostatic Process Regulation Of Axonogenesis Regulation Of Cell Development Signal Transduction By Phosphorylation Neuron Projection Morphogenesis Organelle Organization Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Myofibril Assembly Cell Activation Regulation Of Lamellipodium Assembly Regulation Of Cell Projection Organization Neuron Development Adherens Junction Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Apoptotic Process	Ephrin Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Platelet Activation Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Immune Response Neuron Projection Morphogenesis Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Response To Wounding Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cell Size Neural Fold Formation Innate Immune Response Neuron Projection Development Positive Regulation Of Protein Depolymerization Actin Filament Depolymerization Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Neuron Development Cell Morphogenesis Positive Regulation Of Protein Complex Disassembly Neuron Differentiation Cell Projection Organization Morphogenesis Of An Epithelial Fold Regulation Of Dendritic Spine Morphogenesis Locomotion Immune Response Regulation Of Immune System Process Substantia Nigra Development Defense Response
Tagcloud ?		anxa4 cacybp ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Difference) ?		anxa4 cacybp ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag
Tagcloud (Intersection) ?