CFL1 and CFL2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CFL1	CFL2
Gene Name		cofilin 1 (non-muscle)	cofilin 2 (muscle)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cell-cell Junction Focal Adhesion Membrane Nuclear Matrix Cortical Actin Cytoskeleton Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Vesicular Exosome	Extracellular Space Actin Cytoskeleton Nuclear Matrix I Band Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding	Actin Binding Protein Binding
	Biological Process	Mitotic Cytokinesis Neural Crest Cell Migration Neural Fold Formation Platelet Degranulation Protein Phosphorylation Protein Import Into Nucleus Cytoskeleton Organization Rho Protein Signal Transduction Axon Guidance Blood Coagulation Response To Virus Regulation Of Cell Morphogenesis Establishment Of Cell Polarity Actin Cytoskeleton Organization Actin Filament Depolymerization Platelet Activation Positive Regulation Of Actin Filament Depolymerization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Apoptotic Process Response To Amino Acid Innate Immune Response Negative Regulation Of Cell Size Ephrin Receptor Signaling Pathway Regulation Of Dendritic Spine Morphogenesis	Actin Filament Depolymerization Positive Regulation Of Actin Filament Depolymerization Sarcomere Organization Muscle Cell Cellular Homeostasis Regulation Of Dendritic Spine Morphogenesis
Pathways		Axon guidance Semaphorin interactions Platelet degranulation EPHB-mediated forward signaling Response to elevated platelet cytosolic Ca2+ Sema3A PAK dependent Axon repulsion EPH-Ephrin signaling Platelet activation, signaling and aggregation Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Breast cancer ( 23535729) DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		37 interactors: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CFL2 CLCN5 EGFR HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP NRK POT1 PSEN1 RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 UCHL5 WDR1 YWHAG YWHAQ YWHAZ	8 interactors: ACTB ACTG1 CAP2 CFL1 DSTN LIMK1 POT1 SSH1
Entrez ID		1072	1073
HPRD ID		03261	03262
Ensembl ID		ENSG00000172757	ENSG00000165410
Uniprot IDs		P23528	Q549N0 Q9Y281
PDB IDs		1Q8G 1Q8X 3J0S 4BEX
Enriched GO Terms of Interacting Partners?		Generation Of Neurons Neurogenesis Developmental Process Nervous System Development System Development Multicellular Organismal Development Phosphate-containing Compound Metabolic Process Regulation Of Organelle Organization Cell Differentiation Positive Regulation Of Organelle Organization Anatomical Structure Development Actin Cytoskeleton Organization Cellular Component Assembly Actin Filament-based Process Immune Response-regulating Signaling Pathway Platelet Activation Actomyosin Structure Organization Regulation Of Neurogenesis Anatomical Structure Morphogenesis MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Neuron Differentiation Cell Development Response To Stimulus Axon Guidance Phosphorylation Negative Regulation Of Catalytic Activity Cell Morphogenesis Involved In Neuron Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cellular Component Organization Fc Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Stress Homeostatic Process Regulation Of Axonogenesis Regulation Of Cell Development Signal Transduction By Phosphorylation Neuron Projection Morphogenesis Organelle Organization Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Myofibril Assembly Cell Activation Regulation Of Lamellipodium Assembly Regulation Of Cell Projection Organization Neuron Development Adherens Junction Organization Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Apoptotic Process	Ephrin Receptor Signaling Pathway Axon Guidance Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Morphogenesis Axonogenesis Cytoskeleton Organization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Actin Cytoskeleton Organization Chemotaxis Actin Filament-based Process Neuron Projection Morphogenesis Phagocytosis Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Immune Response-activating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Generation Of Neurons Positive Regulation Of Actin Filament Depolymerization Regulation Of Cellular Component Size Neuron Projection Development Cell Projection Morphogenesis Neurogenesis Cell Part Morphogenesis Regulation Of Actin Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Neuron Development Positive Regulation Of Protein Depolymerization Actin Filament Depolymerization Immune Response-regulating Signaling Pathway Neuron Differentiation Regulation Of Cytoskeleton Organization Cell Projection Organization Nervous System Development Locomotion Anatomical Structure Morphogenesis Positive Regulation Of Protein Complex Disassembly Platelet Activation Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Immune Response Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Tagcloud ?		anxa4 cacybp ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag	adipogenesis adipogenic adipose ankrd1 ankyrin bovine bulls cofilin dehydrogenase differentially hspb1 lactate ldhb likewise mlc1 monitored myogenesis myogenic myosin repeat skeletal steers taldo1 tenfold testosterone threefold transaldolase twofold vary
Tagcloud (Difference) ?		anxa4 cacybp ciapin1 ctro cytokinesis fam50a incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 tpd52l2 trio ube2m ywhag	adipogenesis adipogenic adipose ankrd1 ankyrin bovine bulls cofilin dehydrogenase differentially lactate ldhb likewise mlc1 monitored myogenesis myogenic myosin repeat skeletal steers taldo1 tenfold testosterone threefold transaldolase twofold vary
Tagcloud (Intersection) ?		hspb1