PAIP1 and UBR5

Number of citations of the paper that reports this interaction (PMID 11287654)
22

Data Source:
HPRD (in vitro)

		PAIP1	UBR5
Gene Name		poly(A) binding protein interacting protein 1	ubiquitin protein ligase E3 component n-recognin 5
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Membrane
	Molecular Function	RNA Binding Protein Binding Translation Activator Activity	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translational Initiation Gene Expression Positive Regulation Of Translation MRNA Stabilization	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Proliferation Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of Catenin Import Into Nucleus Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Progesterone Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: EIF4A1 PABPC1 UBR5 WWP2	23 interactors: BARD1 CIB1 DYRK2 GSK3B KPNA1 KPNA2 KPNB1 MAPK1 NR1I2 PAIP1 PAIP2 PGR SATB1 SMAD2 TCEA1 TOPBP1 TP53 UBC UBE2A UBE2B UBE2D2 UBE2D3 UBE2L3
Entrez ID		10605	51366
HPRD ID		05539	06436
Ensembl ID		ENSG00000172239	ENSG00000104517
Uniprot IDs		Q9H074	E7EMW7 O95071
PDB IDs		1JH4 3NTW 3RK6	1I2T 2QHO 3PT3
Enriched GO Terms of Interacting Partners?		Cellular Macromolecule Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process MRNA 3'-end Processing RNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Protein Polyubiquitination RNA Catabolic Process Negative Regulation Of Histone H2A K63-linked Ubiquitination Translational Initiation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Histone Ubiquitination Negative Regulation Of Protein K63-linked Ubiquitination Progesterone Receptor Signaling Pathway Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair Cellular Protein Metabolic Process Negative Regulation Of DNA Repair Positive Regulation Of Catenin Import Into Nucleus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Processing Positive Regulation Of Protein Import Into Nucleus, Translocation Aromatic Compound Catabolic Process Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of MRNA 3'-end Processing MRNA Metabolic Process Protein Metabolic Process Regulation Of Protein Import Into Nucleus, Translocation Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process RNA Processing Protein Ubiquitination Positive Regulation Of MRNA Catabolic Process Regulation Of Catenin Import Into Nucleus Protein Modification By Small Protein Conjugation Protein Catabolic Process Regulation Of Protein Transport MRNA Stabilization Regulation Of Double-strand Break Repair Translation Regulation Of Establishment Of Protein Localization Regulation Of Potassium Ion Transmembrane Transporter Activity	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Response To Organic Substance Nitrogen Compound Metabolic Process Cellular Response To Stress Protein Polyubiquitination DNA Repair Cellular Response To Stimulus Protein K11-linked Ubiquitination Response To Organic Substance Apoptotic Process Programmed Cell Death Cell Death Death Response To Stimulus Viral Process Cellular Macromolecule Catabolic Process Protein K48-linked Ubiquitination Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Protein Import Into Nucleus Nuclear Import Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Nucleocytoplasmic Transport Regulation Of Intracellular Transport Nuclear Transport Negative Regulation Of Gene Expression Protein Import Positive Regulation Of Metabolic Process Response To Abiotic Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway Protein Localization To Nucleus Positive Regulation Of Macromolecule Biosynthetic Process MyD88-independent Toll-like Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Toll-like Receptor 3 Signaling Pathway Cellular Response To Growth Factor Stimulus Protein Ubiquitination Cellular Response To Cytokine Stimulus Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Response To Growth Factor NLS-bearing Protein Import Into Nucleus Toll-like Receptor 4 Signaling Pathway
Tagcloud ?		4g abrogated consequent eif3 eif3f eif3g eif4g enhancement eukaryotic initiation interacting interaction mtorc1 pabp phosphorylate phosphorylates poly pp242 rapamycin ribosomal s6 s6k s6k1 shrna simultaneous stimulate stimulates tail translation	aberrations abt achilles atm aurora birc3 bruton continues descending driver engagement exploited give heel ibrutinib impressive lethal mantle mcl microenvironment nevertheless noncanonical notch1 recurrently ribose sox traf2 underscored vulnerabilities
Tagcloud (Difference) ?		4g abrogated consequent eif3 eif3f eif3g eif4g enhancement eukaryotic initiation interacting interaction mtorc1 pabp phosphorylate phosphorylates poly pp242 rapamycin ribosomal s6 s6k s6k1 shrna simultaneous stimulate stimulates tail translation	aberrations abt achilles atm aurora birc3 bruton continues descending driver engagement exploited give heel ibrutinib impressive lethal mantle mcl microenvironment nevertheless noncanonical notch1 recurrently ribose sox traf2 underscored vulnerabilities
Tagcloud (Intersection) ?