CDK4 and ZNF335

Number of citations of the paper that reports this interaction (PMID 22094256)
37

Data Source:
BioGRID (enzymatic study)

		CDK4	ZNF335
Gene Name		cyclin-dependent kinase 4	zinc finger protein 335
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Tight Junction Nuclear Membrane Perinuclear Region Of Cytoplasm	Nucleus Histone Methyltransferase Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin Binding Protein Complex Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Lens Development In Camera-type Eye Chromatin Organization Protein Phosphorylation Signal Transduction Circadian Rhythm Positive Regulation Of Cell Proliferation Response To Toxic Substance Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Organ Regeneration Response To Testosterone Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Translation Positive Regulation Of Cell Size Regulation Of Protein Kinase Activity Positive Regulation Of Fibroblast Proliferation Cell Division Response To Hyperoxia Negative Regulation Of Cell Cycle Arrest	In Utero Embryonic Development Positive Regulation Of Neuroblast Proliferation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Brain Development Cerebral Cortex Neuron Differentiation Regulation Of Gene Expression, Epigenetic Neuron Projection Morphogenesis Brain Morphogenesis Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Neurogenesis Regulation Of Histone H3-K4 Methylation Histone H3-K4 Trimethylation
Pathways		Meiotic recombination Chromatin organization Ubiquitin-dependent degradation of Cyclin D Cellular Senescence G1 Phase Senescence-Associated Secretory Phenotype (SASP) S Phase Oncogene Induced Senescence Cell Cycle, Mitotic Ubiquitin-dependent degradation of Cyclin D1 RMTs methylate histone arginines Cyclin D associated events in G1 Chromatin modifying enzymes Oxidative Stress Induced Senescence Transcriptional regulation of white adipocyte differentiation Mitotic G1-G1/S phases
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 21383967)
Protein-Protein Interactions		90 interactors: ANKRD12 ANXA7 APLP1 APP ARID4A ATP5B BAG6 BCL11A BIRC5 BMPR1B BRCA1 CAMK1 CAPNS1 CCND1 CCND2 CCND3 CDC37 CDC45 CDC6 CDC7 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CEBPA CIB1 CNOT7 DAZAP2 DDAH2 DUSP9 FOXM1 GLI1 H1F0 HIST1H1A HIST1H1D HMGXB3 HOOK1 IFI27 IL15RA LUC7L2 MAPRE2 MARCKS MCM2 MYC MYOD1 MZF1 NCOA2 NOL12 ORC3 OTX2 PGD PKM POLD1 PPP2R1B PRKAR1A PSMD10 PTMA QARS RB1 RBL1 RBL2 RFC1 RFC4 RPL34 SENP3 SERTAD1 SETDB1 SHOX2 SKP1 SLBP SMAD2 SMAD3 SNCA TGFBR1 TK1 TRMT2A TSPYL2 UBTF UHRF2 VTA1 WDR33 ZBTB16 ZNF101 ZNF219 ZNF335 ZNF655 ZSCAN1	4 interactors: CCAR2 CDK4 CDK6 NCOA6
Entrez ID		1019	63925
HPRD ID		00447	11709
Ensembl ID		ENSG00000135446	ENSG00000198026
Uniprot IDs		P11802 Q6LC83	Q8IW09 Q9H4Z2
PDB IDs		1LD2 2W96 2W99 2W9F 2W9Z 3G33
Enriched GO Terms of Interacting Partners?		Cell Cycle Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Gene Expression Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Gene Expression Regulation Of Cell Proliferation Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Cycle RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Phosphorylation Gene Expression Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Phosphorylation Chromosome Organization Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process	Positive Regulation Of Fibroblast Proliferation Regulation Of Fibroblast Proliferation Positive Regulation Of DNA Damage Checkpoint Cell Dedifferentiation Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Rhythmic Process Positive Regulation Of Gene Expression Glucocorticoid Receptor Signaling Pathway Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Cellular Senescence Positive Regulation Of Cell Size Positive Regulation Of Cell Cycle Checkpoint Regulation Of Gene Expression Cell Division Regulation Of DNA Damage Checkpoint Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression Hematopoietic Stem Cell Differentiation Negative Regulation Of Cell Aging Regulation Of Cell Cycle Process Dentate Gyrus Development Type B Pancreatic Cell Development Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Astrocyte Development Positive Regulation Of Cell Death Type B Pancreatic Cell Differentiation Negative Regulation Of Cell Cycle Arrest Lateral Ventricle Development Enteroendocrine Cell Differentiation Hemopoiesis Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cellular Senescence Response To Lead Ion Mitochondrial Fission Labyrinthine Layer Blood Vessel Development Response To Hyperoxia Mitotic Cell Cycle Process Glandular Epithelial Cell Development Regulation Of Cellular Response To Heat Immune System Development Response To Testosterone
Tagcloud ?		aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing prame ref tab trp tyrosinase uncloned
Tagcloud (Difference) ?		aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing prame ref tab trp tyrosinase uncloned
Tagcloud (Intersection) ?