CDK4 and CNOT7

Number of citations of the paper that reports this interaction (PMID 10602502)
29

Data Source:
HPRD (in vivo)

		CDK4	CNOT7
Gene Name		cyclin-dependent kinase 4	CCR4-NOT transcription complex, subunit 7
Image
Gene Ontology Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Tight Junction Nuclear Membrane Perinuclear Region Of Cytoplasm	Cytoplasmic MRNA Processing Body Nucleus Cytosol Membrane CCR4-NOT Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cyclin Binding Protein Complex Binding	3'-5'-exoribonuclease Activity Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Exoribonuclease Activity Poly(A)-specific Ribonuclease Activity Signal Transducer Activity Protein Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Lens Development In Camera-type Eye Chromatin Organization Protein Phosphorylation Signal Transduction Circadian Rhythm Positive Regulation Of Cell Proliferation Response To Toxic Substance Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Organ Regeneration Response To Testosterone Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Translation Positive Regulation Of Cell Size Regulation Of Protein Kinase Activity Positive Regulation Of Fibroblast Proliferation Cell Division Response To Hyperoxia Negative Regulation Of Cell Cycle Arrest	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Carbohydrate Metabolic Process Transcription, DNA-templated Regulation Of Translation Signal Transduction Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Gene Expression Negative Regulation Of Gene Expression Gene Silencing By RNA Cytoplasmic MRNA Processing Body Assembly Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways		Meiotic recombination Chromatin organization Ubiquitin-dependent degradation of Cyclin D Cellular Senescence G1 Phase Senescence-Associated Secretory Phenotype (SASP) S Phase Oncogene Induced Senescence Cell Cycle, Mitotic Ubiquitin-dependent degradation of Cyclin D1 RMTs methylate histone arginines Cyclin D associated events in G1 Chromatin modifying enzymes Oxidative Stress Induced Senescence Transcriptional regulation of white adipocyte differentiation Mitotic G1-G1/S phases	Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 21383967)
Protein-Protein Interactions		90 interactors: ANKRD12 ANXA7 APLP1 APP ARID4A ATP5B BAG6 BCL11A BIRC5 BMPR1B BRCA1 CAMK1 CAPNS1 CCND1 CCND2 CCND3 CDC37 CDC45 CDC6 CDC7 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CEBPA CIB1 CNOT7 DAZAP2 DDAH2 DUSP9 FOXM1 GLI1 H1F0 HIST1H1A HIST1H1D HMGXB3 HOOK1 IFI27 IL15RA LUC7L2 MAPRE2 MARCKS MCM2 MYC MYOD1 MZF1 NCOA2 NOL12 ORC3 OTX2 PGD PKM POLD1 PPP2R1B PRKAR1A PSMD10 PTMA QARS RB1 RBL1 RBL2 RFC1 RFC4 RPL34 SENP3 SERTAD1 SETDB1 SHOX2 SKP1 SLBP SMAD2 SMAD3 SNCA TGFBR1 TK1 TRMT2A TSPYL2 UBTF UHRF2 VTA1 WDR33 ZBTB16 ZNF101 ZNF219 ZNF335 ZNF655 ZSCAN1	16 interactors: APP BTG1 BTG2 BTG3 CDK1 CDK2 CDK4 CDK6 CNOT6 FOXC2 HOXD4 IKBKG PABPC1 TNRC6A TOB1 TOB2
Entrez ID		1019	29883
HPRD ID		00447	05370
Ensembl ID		ENSG00000135446	ENSG00000198791
Uniprot IDs		P11802 Q6LC83	Q9UIV1
PDB IDs		1LD2 2W96 2W99 2W9F 2W9Z 3G33	2D5R 4GMJ
Enriched GO Terms of Interacting Partners?		Cell Cycle Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Kinase Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Gene Expression Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Gene Expression Regulation Of Cell Proliferation Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Cycle RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Phosphorylation Gene Expression Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Phosphorylation Chromosome Organization Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process	Regulation Of Translation Regulation Of Gene Expression Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of MRNA 3'-end Processing Regulation Of MRNA 3'-end Processing Regulation Of Protein Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Notch Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cell Proliferation G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Gene Silencing By RNA Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cellular Process Regulation Of Cell Cycle MRNA 3'-end Processing Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Translation Regulation Of MRNA Processing Positive Regulation Of Cell Cycle Regulation Of Cell Differentiation Gene Silencing Regulation Of Nitrogen Compound Metabolic Process RNA 3'-end Processing Positive Regulation Of Mitotic Cell Cycle Dentate Gyrus Development Negative Regulation Of Cell Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Gene Expression Positive Regulation Of Cell Proliferation Cell Division MRNA Polyadenylation Regulation Of Apoptotic Process Gene Silencing By MiRNA RNA Polyadenylation
Tagcloud ?		aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing prame ref tab trp tyrosinase uncloned	actr1a backgrounds bbs2 bovines c2orf29 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia ranbp10 rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Difference) ?		aberrantly acetylglucosaminyltransferase antigens bage ctl ecto fig fm3 fm57 gage gp100 immunogenic immunogenicity in4 maa mage mart melan melanocyte melanomas p15 pbl permitted pointing prame ref tab trp tyrosinase uncloned	actr1a backgrounds bbs2 bovines c2orf29 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia ranbp10 rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Intersection) ?