HDAC5 and NRIP1

Number of citations of the paper that reports this interaction (PMID 15060175)
15

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, in vivo)

		HDAC5	NRIP1
Gene Name		histone deacetylase 5	nuclear receptor interacting protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body	Histone Deacetylase Complex Nucleus Nucleoplasm Nucleolus Nuclear Speck Cell Junction
	Molecular Function	Core Promoter Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Repressing Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)	Core Promoter Sequence-specific DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Estrogen Receptor Binding Nuclear Hormone Receptor Binding Glucocorticoid Receptor Binding Histone Deacetylase Binding Retinoid X Receptor Binding Androgen Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Development Chromatin Organization Chromatin Remodeling Chromatin Silencing Transcription, DNA-templated Inflammatory Response Notch Signaling Pathway Heart Development Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Chromatin Modification Histone Deacetylation B Cell Differentiation Cellular Response To Insulin Stimulus Multicellular Organismal Response To Stress Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Cocaine Response To Drug Regulation Of Protein Binding Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ovarian Follicle Rupture Transcription, DNA-templated Circadian Rhythm Lipid Storage Androgen Receptor Signaling Pathway Circadian Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982)	Breast cancer ( 23535729) Cognitive performance ( 19734545)
Protein-Protein Interactions		59 interactors: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE YWHAQ ZBTB16	53 interactors: ACTN2 AHR APP AR ARPC3 BRCA1 CCDC85B CDK8 CEP70 CIB1 CTBP1 CTBP2 DNMT1 DNMT3A DNMT3B E2F1 ESR1 ESR2 ESRRA ESRRB ESRRG HDAC1 HDAC2 HDAC3 HDAC5 HDAC9 HNF4A JUN KAT2B LDOC1 MAP3K7 NR0B1 NR1H2 NR1H3 NR2C1 NR3C1 NR5A1 NR5A2 PPARA PPARD PPARG PRMT1 RARA RORB RXRA RXRB TEX11 THRA THRB TNFRSF14 TRAF2 VDR YWHAH
Entrez ID		10014	8204
HPRD ID		09246	03927
Ensembl ID		ENSG00000108840	ENSG00000180530
Uniprot IDs		Q9UQL6	A8K171 P48552
PDB IDs			2GPO 2GPP
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Negative Regulation Of Gene Expression Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process System Development Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Developmental Process Anatomical Structure Development Cell Differentiation Regulation Of Cell Death Multicellular Organismal Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Protein Deacetylation	Steroid Hormone Mediated Signaling Pathway Intracellular Receptor Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Steroid Hormone Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Positive Regulation Of Gene Expression Cellular Response To Hormone Stimulus Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Response To Organic Substance Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Steroid Hormone Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Response To Organic Cyclic Compound Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Response To Hormone Gene Expression Response To Lipid Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Signal Transduction
Tagcloud ?		125a 5p activating anticancer apoptosis converse deacetylase detailed doi downregulation exist hdaci implications induce intrinsic involving loop mediates microrna mir mt nevertheless runx3 silenced silencing subsequently transcriptionally tumorigenesis	accurately blastx classifications close cog degs density differentially downloaded enriched esr1 genecodis gotm gse7429 hundred includes language mapped mineral module modules obtain omnibus osteoprotegerin packages ppid searched software vdr
Tagcloud (Difference) ?		125a 5p activating anticancer apoptosis converse deacetylase detailed doi downregulation exist hdaci implications induce intrinsic involving loop mediates microrna mir mt nevertheless runx3 silenced silencing subsequently transcriptionally tumorigenesis	accurately blastx classifications close cog degs density differentially downloaded enriched esr1 genecodis gotm gse7429 hundred includes language mapped mineral module modules obtain omnibus osteoprotegerin packages ppid searched software vdr
Tagcloud (Intersection) ?