HDAC5 and NFKB2

Number of citations of the paper that reports this interaction (PMID 12917325)
12

Data Source:
HPRD (in vivo, in vitro)

		HDAC5	NFKB2
Gene Name		histone deacetylase 5	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body	Nucleus Nucleoplasm Cytoplasm Cytosol Bcl3/NF-kappaB2 Complex
	Molecular Function	Core Promoter Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Repressing Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Development Chromatin Organization Chromatin Remodeling Chromatin Silencing Transcription, DNA-templated Inflammatory Response Notch Signaling Pathway Heart Development Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Chromatin Modification Histone Deacetylation B Cell Differentiation Cellular Response To Insulin Stimulus Multicellular Organismal Response To Stress Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Cocaine Response To Drug Regulation Of Protein Binding Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor Signaling Pathway Follicular Dendritic Cell Differentiation Germinal Center Formation MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Regulation Of Transcription, DNA-templated Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Extracellular Matrix Organization Positive Regulation Of Type I Interferon Production Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Spleen Development Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Signaling by Interleukins Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 processing TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982)
Protein-Protein Interactions		59 interactors: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE YWHAQ ZBTB16	35 interactors: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2
Entrez ID		10014	4791
HPRD ID		09246	01239
Ensembl ID		ENSG00000108840	ENSG00000077150
Uniprot IDs		Q9UQL6	Q00653
PDB IDs			1A3Q 2D96 3DO7
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Negative Regulation Of Gene Expression Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process System Development Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Developmental Process Anatomical Structure Development Cell Differentiation Regulation Of Cell Death Multicellular Organismal Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Protein Deacetylation	I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Immune System Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Toll-like Receptor 3 Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Type I Interferon Production Activation Of Innate Immune Response Gene Expression Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway RNA Metabolic Process Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Transcription, DNA-templated TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Pattern Recognition Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Innate Immune Response-activating Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Macromolecule Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Cytokine Production Negative Regulation Of Gene Expression Intracellular Signal Transduction
Tagcloud ?		125a 5p activating anticancer apoptosis converse deacetylase detailed doi downregulation exist hdaci implications induce intrinsic involving loop mediates microrna mir mt nevertheless runx3 silenced silencing subsequently transcriptionally tumorigenesis	arrangement bcl cbcl cbcls clonal clonality cls ctcl ctcls cutaneous deletions extranodal germline hodgkin ig lymphoid lymphomas lyt malignancies neoplasias nodal oncogenes pathogenetic rearrangement rearrangements southern tal tcr undetectable
Tagcloud (Difference) ?		125a 5p activating anticancer apoptosis converse deacetylase detailed doi downregulation exist hdaci implications induce intrinsic involving loop mediates microrna mir mt nevertheless runx3 silenced silencing subsequently transcriptionally tumorigenesis	arrangement bcl cbcl cbcls clonal clonality cls ctcl ctcls cutaneous deletions extranodal germline hodgkin ig lymphoid lymphomas lyt malignancies neoplasias nodal oncogenes pathogenetic rearrangement rearrangements southern tal tcr undetectable
Tagcloud (Intersection) ?