NR2E3 and DEDD2

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		NR2E3	DEDD2
Gene Name		nuclear receptor subfamily 2, group E, member 3	death effector domain containing 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex	Nucleoplasm Nucleolus
	Molecular Function	Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	DNA Binding Protein Binding Receptor Signaling Complex Scaffold Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Visual Perception Phototransduction Negative Regulation Of Cell Proliferation Gene Expression Intracellular Receptor Signaling Pathway Eye Photoreceptor Cell Development Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Rhodopsin Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Retina Development In Camera-type Eye	Transcription, DNA-templated RNA Processing Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors RRNA Catabolic Process Cellular Homeostasis Apoptotic Nuclear Changes Intracellular Signal Transduction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Metabolite levels (HVA/MHPG ratio) ( 23319000)
Protein-Protein Interactions		27 interactors: BCL11A CDK9 CRX DEDD2 DHX30 ELAVL2 HDAC1 HDAC3 HOXC13 IRF9 MYBBP1A NCOR1 NR1D1 NR3C1 POLR3D PPARG RARA RBBP4 RBBP7 RBFOX2 RBL1 RXRA RXRB SIN3A SNAPC1 TBL3 ZNF232	11 interactors: CASP10 CASP8 CDCA7L CDK6 CFLAR DEDD GTF3C3 HNRNPAB NR2E3 RBFOX2 RHOXF2
Entrez ID		10002	162989
HPRD ID		05132	10868
Ensembl ID			ENSG00000160570
Uniprot IDs		B6ZGU0 F1D8Q9 Q9Y5X4	Q8WXF8
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-templated Transcription, Initiation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Steroid Hormone Mediated Signaling Pathway Intracellular Receptor Signaling Pathway Cellular Metabolic Process Hormone-mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Circadian Regulation Of Gene Expression Circadian Rhythm Rhythmic Process Cellular Response To Steroid Hormone Stimulus Chromatin Modification Positive Regulation Of Metabolic Process Chromatin Organization Regulation Of Receptor Biosynthetic Process Response To Organic Substance	Regulation Of Necroptotic Process Regulation Of Necrotic Cell Death Tissue Development Regulation Of Myeloid Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Intracellular Receptor Signaling Pathway Organ Development Regulation Of Erythrocyte Differentiation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Gene Expression Regulation Of Cell Proliferation Apoptotic Signaling Pathway Cell Dedifferentiation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Development Programmed Cell Death Activation Of Cysteine-type Endopeptidase Activity System Development Regulation Of Metabolic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Cell Death Death Extrinsic Apoptotic Signaling Pathway Regulation Of Transcription, DNA-templated Zymogen Activation Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Rhodopsin Gene Expression Negative Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Rhodopsin Gene Expression Negative Regulation Of Myoblast Fusion Multicellular Organismal Development Positive Regulation Of Peptidase Activity Cell Differentiation Negative Regulation Of Gene Expression Radial Glia Guided Migration Of Purkinje Cell Regulation Of Definitive Erythrocyte Differentiation Anatomical Structure Development Negative Regulation Of Biosynthetic Process
Tagcloud ?		11a causing compound correlates cytotoxic cytotoxicity eralpha excluding facilitate favorable hct116 hela implying isogenic mediator mutated nci null orphan p53 photoreceptor pleiotropic pnr responsive retain retinal systematic tamoxifen varying	annotation atra bindings birc3 braf casp4 casp8 changed effector erk expressions fas fate fenretinide fewer hspa1a huh7 inducing mek participated profiled raf ras rxralpha sosc2 tnfaip3 tnfalpha traf2 uses
Tagcloud (Difference) ?		11a causing compound correlates cytotoxic cytotoxicity eralpha excluding facilitate favorable hct116 hela implying isogenic mediator mutated nci null orphan p53 photoreceptor pleiotropic pnr responsive retain retinal systematic tamoxifen varying	annotation atra bindings birc3 braf casp4 casp8 changed effector erk expressions fas fate fenretinide fewer hspa1a huh7 inducing mek participated profiled raf ras rxralpha sosc2 tnfaip3 tnfalpha traf2 uses
Tagcloud (Intersection) ?