Search Results for: HSP90AA1

164 interactions involving HSP90AA1 - heat shock protein 90 alpha family class A member 1 found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
NR2C2 nuclear receptor subfamily 2 group C member 2
  • Nuclear Receptor transcription pathway
NR3C1 nuclear receptor subfamily 3 group C member 1
  • HSP90 chaperone cycle for steroid hormone receptors (SHR)
  • Circadian Clock
  • SUMOylation of intracellular receptors
  • PTK6 Expression
  • Regulation of RUNX2 expression and activity
  • FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
  • Potential therapeutics for SARS
  • Flunisolide
  • Diflorasone
  • Alclometasone
  • Medrysone
  • Amcinonide
  • Fluorometholone
  • Megestrol acetate
  • Levonorgestrel
  • Beclomethasone dipropionate
  • Progesterone
  • Spironolactone
  • Betamethasone
  • Desoximetasone
  • Fluticasone propionate
  • Fluocinolone acetonide
  • Ulobetasol
  • Triamcinolone
  • Prednisone
  • Flumethasone
  • Fludrocortisone
  • Norethisterone
  • Hydrocortisone
  • Mometasone
  • Hydrocortamate
  • Mifepristone
  • Clocortolone
  • Flurandrenolide
  • Prednisolone
  • Loteprednol etabonate
  • Rimexolone
  • Methylprednisolone
  • Clobetasol propionate
  • Fluocinonide
  • Prednicarbate
  • Fluoxymesterone
  • Budesonide
  • Dexamethasone
  • Desonide
  • Cortisone acetate
  • Paramethasone
  • Drospirenone
  • Ciclesonide
  • Hexane-1,6-Diol
  • Aldosterone
  • ORG-34517
  • Difluprednate
  • Ulipristal
  • Fluticasone furoate
  • Tixocortol
  • Difluocortolone
  • Gestrinone
  • Deflazacort
  • Onapristone
  • Cortivazol
  • Clobetasone
  • Fluticasone
  • Mometasone furoate
  • Hydrocortisone aceponate
  • Hydrocortisone acetate
  • Hydrocortisone butyrate
  • Hydrocortisone cypionate
  • Hydrocortisone phosphate
  • Hydrocortisone probutate
  • Hydrocortisone valerate
  • Segesterone acetate
  • Prednisolone phosphate
  • Dexamethasone acetate
  • Betamethasone phosphate
  • Prednisolone acetate
  • 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
NR3C2 nuclear receptor subfamily 3 group C member 2
  • HSP90 chaperone cycle for steroid hormone receptors (SHR)
  • SUMOylation of intracellular receptors
  • Nimodipine
  • Progesterone
  • Spironolactone
  • Fluticasone propionate
  • Testosterone
  • Fludrocortisone
  • Eplerenone
  • Clobetasol propionate
  • Felodipine
  • Desoxycorticosterone pivalate
  • Drospirenone
  • Stanolone
  • Metribolone
  • Aldosterone
  • Corticosterone
  • Desoxycorticosterone acetate
  • Fluticasone furoate
  • Fluticasone
  • Testosterone cypionate
  • Testosterone enanthate
  • Testosterone undecanoate
  • Stanolone acetate
  • Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
  • Hypertension exacerbated in pregnancy
NSL1 NSL1 component of MIS12 kinetochore complex
  • Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
  • Separation of Sister Chromatids
  • Resolution of Sister Chromatid Cohesion
  • RHO GTPases Activate Formins
  • Mitotic Prometaphase
  • EML4 and NUDC in mitotic spindle formation
PABPN1 poly(A) binding protein nuclear 1
  • Inhibition of Host mRNA Processing and RNA Silencing
  • mRNA Splicing - Major Pathway
  • mRNA 3'-end processing
  • RNA Polymerase II Transcription Termination
  • Processing of Intronless Pre-mRNAs
  • Oculopharyngeal muscular dystrophy (OPMD)
PAK1 p21 (RAC1) activated kinase 1
  • Generation of second messenger molecules
  • Regulation of actin dynamics for phagocytic cup formation
  • FCERI mediated MAPK activation
  • FCERI mediated MAPK activation
  • DSCAM interactions
  • CD28 dependent Vav1 pathway
  • EPHB-mediated forward signaling
  • Ephrin signaling
  • Sema3A PAK dependent Axon repulsion
  • Activation of RAC1
  • Signal transduction by L1
  • Smooth Muscle Contraction
  • VEGFR2 mediated vascular permeability
  • CD209 (DC-SIGN) signaling
  • RHO GTPases activate PKNs
  • RHO GTPases Activate ROCKs
  • RHO GTPases activate PAKs
  • RHO GTPases activate PAKs
  • MAPK6/MAPK4 signaling
  • G beta:gamma signalling through CDC42
  • Fostamatinib
PDPK1 3-phosphoinositide dependent protein kinase 1
  • GPVI-mediated activation cascade
  • GPVI-mediated activation cascade
  • PIP3 activates AKT signaling
  • Activation of AKT2
  • Downstream TCR signaling
  • Role of LAT2/NTAL/LAB on calcium mobilization
  • FCERI mediated NF-kB activation
  • Integrin signaling
  • CD28 dependent PI3K/Akt signaling
  • G beta:gamma signalling through PI3Kgamma
  • RSK activation
  • VEGFR2 mediated vascular permeability
  • VEGFR2 mediated cell proliferation
  • CLEC7A (Dectin-1) signaling
  • RHO GTPases activate PKNs
  • Constitutive Signaling by AKT1 E17K in Cancer
  • Regulation of TP53 Degradation
  • Estrogen-stimulated signaling through PRKCZ
  • Estrogen-stimulated signaling through PRKCZ
  • Celecoxib
  • Inositol 1,3,4,5-Tetrakisphosphate
  • 7-Hydroxystaurosporine
  • Bisindolylmaleimide VIII
  • Staurosporine
  • Bisindolylmaleimide I
  • Dexfosfoserine
  • 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine
  • 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE
  • 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA
  • 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine
  • 3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione
  • 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
  • Fostamatinib
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
  • Interleukin-4 and Interleukin-13 signaling
  • STAT5 activation downstream of FLT3 ITD mutants
  • Signaling by FLT3 fusion proteins
  • 3,4-Dihydroxy-1-Methylquinolin-2(1h)-One
  • Staurosporine
  • LY-294002
  • Imidazole
  • (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One
  • Bisindolylmaleimide I
  • Quercetin
  • Phosphoaminophosphonic Acid-Adenylate Ester
  • Dexfosfoserine
  • S,S-(2-Hydroxyethyl)Thiocysteine
  • IMIDAZOPYRIDAZIN 1
  • 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one
  • (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile
  • N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine
  • (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile
  • (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile
  • Tricetin
  • 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE
  • 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine
  • N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine
  • 2,3-diphenyl-1H-indole-7-carboxylic acid
  • Fostamatinib
PMF1 polyamine modulated factor 1
  • Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
  • Separation of Sister Chromatids
  • Resolution of Sister Chromatid Cohesion
  • RHO GTPases Activate Formins
  • Mitotic Prometaphase
  • EML4 and NUDC in mitotic spindle formation
PPARA peroxisome proliferator activated receptor alpha
  • RORA activates gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • PPARA activates gene expression
  • Transcriptional activation of mitochondrial biogenesis
  • Activation of gene expression by SREBF (SREBP)
  • Transcriptional regulation of white adipocyte differentiation
  • Nuclear Receptor transcription pathway
  • Regulation of lipid metabolism by PPARalpha
  • Circadian Clock
  • SUMOylation of intracellular receptors
  • alpha-Linolenic acid
  • Icosapent
  • Troglitazone
  • Valproic acid
  • Indomethacin
  • Rosiglitazone
  • Fenoprofen
  • Clofibrate
  • Fenofibrate
  • Ibuprofen
  • Amiodarone
  • Gemfibrozil
  • Bezafibrate
  • Prasterone
  • N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide
  • Flufenamic acid
  • Resveratrol
  • Phthalic Acid
  • Lauric acid
  • Stearic acid
  • Doconexent
  • Palmitic Acid
  • Oleic Acid
  • Caprylic acid
  • Arachidonic Acid
  • Reglitazar
  • Elafibranor
  • Cardarine
  • Muraglitazar
  • Ertiprotafib
  • Ragaglitazar
  • Tesaglitazar
  • GW-590735
  • Indeglitazar
  • Myristic acid
  • Aleglitazar
  • Clinofibrate
  • Ciprofibrate
  • Dexibuprofen
  • Soybean oil
  • Omega-3 fatty acids
  • Myrrh
  • Isoflavone
  • Leukotriene B4
  • Fenofibric acid
  • Fish oil
PPARD peroxisome proliferator activated receptor delta
  • Carnitine metabolism
  • Regulation of pyruvate dehydrogenase (PDH) complex
  • Nuclear Receptor transcription pathway
  • Signaling by Retinoic Acid
  • alpha-Linolenic acid
  • Icosapent
  • Troglitazone
  • Valproic acid
  • Treprostinil
  • Rosiglitazone
  • Sulindac
  • Bezafibrate
  • Phthalic Acid
  • Heptyl glucoside
  • Oleic Acid
  • cis-Vaccenic acid
  • Elafibranor
  • KD3010
  • Cardarine
  • (2S)-2-{3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]-4-methoxybenzyl}butanoic acid
  • 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid
  • Indeglitazar
  • {4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acid
  • Clinofibrate
  • Glycerin
  • Fenofibric acid
  • Fish oil
PPID peptidylprolyl isomerase D
  • ESR-mediated signaling
PPIL2 peptidylprolyl isomerase like 2
  • Basigin interactions
PPP5C protein phosphatase 5 catalytic subunit
  • Negative regulation of MAPK pathway
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • ESR-mediated signaling
  • ATP
PRKACA protein kinase cAMP-activated catalytic subunit alpha
  • PKA-mediated phosphorylation of CREB
  • PKA-mediated phosphorylation of key metabolic factors
  • Triglyceride catabolism
  • PKA activation
  • PKA activation in glucagon signalling
  • DARPP-32 events
  • Regulation of PLK1 Activity at G2/M Transition
  • Loss of Nlp from mitotic centrosomes
  • Recruitment of mitotic centrosome proteins and complexes
  • Loss of proteins required for interphase microtubule organization from the centrosome
  • Recruitment of NuMA to mitotic centrosomes
  • Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
  • Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
  • Rap1 signalling
  • Regulation of insulin secretion
  • Vasopressin regulates renal water homeostasis via Aquaporins
  • VEGFA-VEGFR2 Pathway
  • CREB1 phosphorylation through the activation of Adenylate Cyclase
  • CREB1 phosphorylation through the activation of Adenylate Cyclase
  • Interleukin-3, Interleukin-5 and GM-CSF signaling
  • Ion homeostasis
  • Degradation of GLI1 by the proteasome
  • Degradation of GLI2 by the proteasome
  • GLI3 is processed to GLI3R by the proteasome
  • Hedgehog 'off' state
  • Anchoring of the basal body to the plasma membrane
  • CD209 (DC-SIGN) signaling
  • MAPK6/MAPK4 signaling
  • RET signaling
  • AURKA Activation by TPX2
  • HDL assembly
  • ROBO receptors bind AKAP5
  • Loss of phosphorylation of MECP2 at T308
  • Regulation of MECP2 expression and activity
  • Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
  • ADORA2B mediated anti-inflammatory cytokines production
  • ADORA2B mediated anti-inflammatory cytokines production
  • FCGR3A-mediated IL10 synthesis
  • FCGR3A-mediated IL10 synthesis
  • Factors involved in megakaryocyte development and platelet production
  • Pentanal
  • Balanol Analog 2
  • 3-[(3-sec-butyl-4-hydroxybenzoyl)amino]azepan-4-yl 4-(2-hydroxy-5-methoxybenzoyl)benzoate
  • Phosphonothreonine
  • Balanol Analog 1
  • 3,5-Diiodotyrosine
  • Balanol
  • Dexfosfoserine
  • S,S-(2-Hydroxyethyl)Thiocysteine
  • Hydroxyfasudil
  • (2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamine
  • (2S)-1-{[5-(1H-Indazol-5-yl)-3-pyridinyl]oxy}-3-(7aH-indol-3-yl)-2-propanamine
  • (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE
  • (2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
  • (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE
  • N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE
  • 3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1H-indol-3-yl}-1H-pyrrole-2,5-dione
  • (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE
  • N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
  • (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE
  • 6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE
  • (2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
  • (2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine
  • 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
  • (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE
  • (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
  • ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
  • H-89
  • 5-(2-methylpiperazine-1-sulfonyl)isoquinoline
  • N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE
  • 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE
  • (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
  • 3-pyridin-4-yl-1H-indazole
  • 5-benzyl-1,3-thiazol-2-amine
  • 1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
  • 1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine
  • 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium
  • Fasudil
  • Myristic acid
  • A-674563
  • 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE
  • Y-27632
  • Ellagic acid
  • Fostamatinib
PRKCA protein kinase C alpha
  • Calmodulin induced events
  • Disinhibition of SNARE formation
  • SHC1 events in ERBB2 signaling
  • Signaling by SCF-KIT
  • Regulation of KIT signaling
  • EGFR Transactivation by Gastrin
  • Inactivation, recovery and regulation of the phototransduction cascade
  • Syndecan interactions
  • Acetylcholine regulates insulin secretion
  • Ca2+ pathway
  • Trafficking of GluR2-containing AMPA receptors
  • G alpha (z) signalling events
  • Depolymerisation of the Nuclear Lamina
  • HuR (ELAVL1) binds and stabilizes mRNA
  • WNT5A-dependent internalization of FZD4
  • VEGFR2 mediated cell proliferation
  • RHO GTPases Activate NADPH Oxidases
  • Response to elevated platelet cytosolic Ca2+
  • RET signaling
  • ROBO receptors bind AKAP5
  • ROBO receptors bind AKAP5
  • Phosphatidyl serine
  • Vitamin E
  • Tamoxifen
  • Ingenol mebutate
  • Aprinocarsen
  • Midostaurin
  • Perifosine
  • Ellagic acid
  • Bryostatin 1
  • alpha-Tocopherol succinate
  • D-alpha-Tocopherol acetate
PRKCD protein kinase C delta
  • Apoptotic cleavage of cellular proteins
  • Calmodulin induced events
  • Effects of PIP2 hydrolysis
  • SHC1 events in ERBB2 signaling
  • DAG and IP3 signaling
  • Role of phospholipids in phagocytosis
  • G alpha (z) signalling events
  • HuR (ELAVL1) binds and stabilizes mRNA
  • VEGFR2 mediated cell proliferation
  • CLEC7A (Dectin-1) signaling
  • RHO GTPases Activate NADPH Oxidases
  • Neutrophil degranulation
  • Interferon gamma signaling
  • Tamoxifen
  • 13-Acetylphorbol
  • Ingenol mebutate
  • Fostamatinib
PRKDC protein kinase, DNA-activated, catalytic subunit
  • Cytosolic sensors of pathogen-associated DNA
  • IRF3-mediated induction of type I IFN
  • Nonhomologous End-Joining (NHEJ)
  • E3 ubiquitin ligases ubiquitinate target proteins
  • Caffeine
  • SF1126
PTGDS prostaglandin D2 synthase
  • Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
  • Transcriptional regulation of testis differentiation
  • Vitamin A
PTGES3 prostaglandin E synthase 3
  • Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
  • HSP90 chaperone cycle for steroid hormone receptors (SHR)
  • HSF1 activation
  • Attenuation phase
  • Aryl hydrocarbon receptor signalling
  • ESR-mediated signaling
  • Estrogen-dependent gene expression
  • Potential therapeutics for SARS
  • Acetaminophen
  • Grn163l
  • Copper

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