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CDKN1A |
cyclin dependent kinase inhibitor 1A |
- SCF(Skp2)-mediated degradation of p27/p21
- AKT phosphorylates targets in the cytosol
- Senescence-Associated Secretory Phenotype (SASP)
- DNA Damage/Telomere Stress Induced Senescence
- Constitutive Signaling by AKT1 E17K in Cancer
- Interleukin-4 and Interleukin-13 signaling
- TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
- Cyclin E associated events during G1/S transition
- Cyclin D associated events in G1
- p53-Dependent G1 DNA Damage Response
- Cyclin A:Cdk2-associated events at S phase entry
- Transcriptional activation of cell cycle inhibitor p21
- The role of GTSE1 in G2/M progression after G2 checkpoint
- TFAP2 (AP-2) family regulates transcription of cell cycle factors
- Transcriptional regulation by RUNX2
- RUNX3 regulates CDKN1A transcription
- Transcriptional regulation of granulopoiesis
- FOXO-mediated transcription of cell cycle genes
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
- STAT5 activation downstream of FLT3 ITD mutants
- Signaling by FLT3 fusion proteins
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CYP17A1 |
cytochrome P450 family 17 subfamily A member 1 |
- Androgen biosynthesis
- Glucocorticoid biosynthesis
- Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
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- NADH
- Progesterone
- Spironolactone
- Ketoconazole
- Abiraterone
- Cannabidiol
- Medical Cannabis
- Nabiximols
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- 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
- Congenital adrenal hyperplasia (CAH)
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DAPK3 |
death associated protein kinase 3 |
- Caspase activation via Dependence Receptors in the absence of ligand
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- 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
- 4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid
- (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile
- Fostamatinib
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DBF4 |
DBF4 zinc finger |
- Activation of ATR in response to replication stress
- Activation of the pre-replicative complex
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DIRAS3 |
DIRAS family GTPase 3 |
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E2F1 |
E2F transcription factor 1 |
- Activation of NOXA and translocation to mitochondria
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Transcription of E2F targets under negative control by DREAM complex
- Transcription of E2F targets under negative control by DREAM complex
- Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
- Activation of PUMA and translocation to mitochondria
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Transcription and Translation
- Oxidative Stress Induced Senescence
- Oncogene Induced Senescence
- TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
- CDC6 association with the ORC:origin complex
- G2 Phase
- Cyclin E associated events during G1/S transition
- G1/S-Specific Transcription
- G1/S-Specific Transcription
- Cyclin D associated events in G1
- Cyclin A:Cdk2-associated events at S phase entry
- Transcriptional Regulation by E2F6
- Transcriptional regulation of granulopoiesis
- Transcriptional regulation of granulopoiesis
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
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ELAVL1 |
ELAV like RNA binding protein 1 |
- HuR (ELAVL1) binds and stabilizes mRNA
- mRNA Splicing - Major Pathway
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ENO1 |
enolase 1 |
- Glycolysis
- Gluconeogenesis
- Manipulation of host energy metabolism
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- Zinc
- Copper
- Artenimol
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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ERCC6 |
ERCC excision repair 6, chromatin remodeling factor |
- ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
- B-WICH complex positively regulates rRNA expression
- Formation of TC-NER Pre-Incision Complex
- Transcription-Coupled Nucleotide Excision Repair (TC-NER)
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- RNA Polymerase I Transcription Initiation
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- Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
- Cockayne syndrome
- Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
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FHL1 |
four and a half LIM domains 1 |
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- X-linked myopathy with postural muscle atrophy (XMPMA)
- Reducing body myopathy (RBM)
- Scapuloperoneal myopathy (SPM)
- Emery-Dreifuss muscular dystrophy
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FHL3 |
four and a half LIM domains 3 |
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FOXM1 |
forkhead box M1 |
- Polo-like kinase mediated events
- Cyclin A/B1/B2 associated events during G2/M transition
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GNAS |
GNAS complex locus |
- Glucagon signaling in metabolic regulation
- PKA activation in glucagon signalling
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Prostacyclin signalling through prostacyclin receptor
- Prostacyclin signalling through prostacyclin receptor
- G alpha (s) signalling events
- G alpha (s) signalling events
- G alpha (i) signalling events
- G alpha (z) signalling events
- Glucagon-type ligand receptors
- Vasopressin regulates renal water homeostasis via Aquaporins
- Hedgehog 'off' state
- ADORA2B mediated anti-inflammatory cytokines production
- ADORA2B mediated anti-inflammatory cytokines production
- Glucagon signaling in metabolic regulation
- PKA activation in glucagon signalling
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
- Prostacyclin signalling through prostacyclin receptor
- Prostacyclin signalling through prostacyclin receptor
- G alpha (s) signalling events
- G alpha (s) signalling events
- G alpha (i) signalling events
- G alpha (z) signalling events
- Glucagon-type ligand receptors
- Vasopressin regulates renal water homeostasis via Aquaporins
- Hedgehog 'off' state
- ADORA2B mediated anti-inflammatory cytokines production
- ADORA2B mediated anti-inflammatory cytokines production
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- Colforsin
- 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE
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- Fibrous dysplasia, polyostotic; Albright hereditary osteodystrophy
- Pseudohypoparathyroidism
- Progressive osseous heteroplasia (POH)
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HMGN1 |
high mobility group nucleosome binding domain 1 |
- Formation of TC-NER Pre-Incision Complex
- Transcription-Coupled Nucleotide Excision Repair (TC-NER)
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
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HOXC6 |
homeobox C6 |
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ITIH5 |
inter-alpha-trypsin inhibitor heavy chain 5 |
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KLK7 |
kallikrein related peptidase 7 |
- Degradation of the extracellular matrix
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- L-alanyl-N-[(1S,2R)-1-benzyl-2-hydroxypropyl]-L-alaninamide
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KLK9 |
kallikrein related peptidase 9 |
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KPNA2 |
karyopherin subunit alpha 2 |
- CaMK IV-mediated phosphorylation of CREB
- ISG15 antiviral mechanism
- NS1 Mediated Effects on Host Pathways
- CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
- Sensing of DNA Double Strand Breaks
- Estrogen-dependent gene expression
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LATS2 |
large tumor suppressor kinase 2 |
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