ESR1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
NONO	non-POU domain containing octamer binding
NPM1	nucleophosmin 1	Nuclear import of Rev protein Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	Artenimol
NPPA	natriuretic peptide A	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Amyloid fiber formation		Atrial fibrillation
NR0B1	nuclear receptor subfamily 0 group B member 1		Dexamethasone Dexamethasone acetate	Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
NR0B2	nuclear receptor subfamily 0 group B member 2	Nuclear Receptor transcription pathway
NR1H4	nuclear receptor subfamily 1 group H member 4	Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols	alpha-Linolenic acid Ursodeoxycholic acid Farnesol Fexaramine Cholic Acid Deoxycholic acid Taurocholic acid Arachidonic Acid Obeticholic acid Chenodeoxycholic acid (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid Myrrh
NR2C1	nuclear receptor subfamily 2 group C member 1	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
NR2C2	nuclear receptor subfamily 2 group C member 2	Nuclear Receptor transcription pathway
NR2F1	nuclear receptor subfamily 2 group F member 1	Nuclear Receptor transcription pathway	beta-Naphthoflavone
NR2F6	nuclear receptor subfamily 2 group F member 6	Nuclear Receptor transcription pathway
NRIP1	nuclear receptor interacting protein 1	SUMOylation of transcription cofactors Circadian Clock Estrogen-dependent gene expression NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
NSD1	nuclear receptor binding SET domain protein 1	PKMTs methylate histone lysines		Beckwith-Wiedemann syndrome Sotos syndrome and Weaver syndrome
NSD2	nuclear receptor binding SET domain protein 2	PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint		Multiple myeloma
NSD3	nuclear receptor binding SET domain protein 3	PKMTs methylate histone lysines
NSF	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	COPII-mediated vesicle transport Trafficking of GluR2-containing AMPA receptors COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	1-Ethyl-Pyrrolidine-2,5-Dione
NUDT21	nudix hydrolase 21	mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
OTUB1	OTU deubiquitinase, ubiquitin aldehyde binding 1	Ub-specific processing proteases Ovarian tumor domain proteases
P4HB	prolyl 4-hydroxylase subunit beta	Collagen biosynthesis and modifying enzymes Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Interleukin-12 signaling Interleukin-23 signaling	Zinc Ribostamycin Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
PA2G4	proliferation-associated 2G4	Neutrophil degranulation
PAGR1	PAXIP1 associated glutamate rich protein 1	Activation of anterior HOX genes in hindbrain development during early embryogenesis

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