PUM3 and GPER1

Data Source:
BioGRID (affinity chromatography technology)

		PUM3	GPER1
Description		pumilio RNA binding family member 3	G protein-coupled estrogen receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus Endoplasmic Reticulum	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Nucleolus Cytoplasm Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Axon Dendrite Cytoplasmic Vesicle Membrane Mitochondrial Membrane Dendritic Spine Membrane Presynaptic Membrane Dendritic Shaft Intracellular Membrane-bounded Organelle Axon Terminus Dendritic Spine Head Keratin Filament Perinuclear Region Of Cytoplasm Presynaptic Active Zone Recycling Endosome
	Molecular Function	DNA Binding RNA Binding MRNA Binding Protein Binding	Chromatin Binding Steroid Hormone Receptor Activity G Protein-coupled Receptor Activity Steroid Binding Protein Binding Estrogen Receptor Activity Steroid Hormone Binding
	Biological Process	Regulation Of Translation Regulation Of Protein ADP-ribosylation	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Neurotransmitter Secretion Negative Regulation Of Leukocyte Activation Inflammatory Response Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cell Cycle Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Neuronal Action Potential Apoptotic Chromosome Condensation Nuclear Fragmentation Involved In Apoptotic Nuclear Change Positive Regulation Of Cell Migration Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Vasodilation Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of MAPK Cascade Innate Immune Response Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Neurogenesis Negative Regulation Of Lipid Biosynthetic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Uterine Smooth Muscle Contraction Negative Regulation Of Cell Cycle Arrest Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Peptide Hormone Stimulus Cellular Response To Mineralocorticoid Stimulus Cellular Response To Estradiol Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Peptide ligand-binding receptors G alpha (i) signalling events
Drugs			Estradiol Genistein MK-0354 Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
Diseases
GWAS		Depression ( 29700475) Waist circumference adjusted for body mass index ( 28552196)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		4 interacting genes: APP CALM1 HPS6 ITGB1BP2
Entrez ID		9933	2852
HPRD ID		08822	03484
Ensembl ID		ENSG00000080608	ENSG00000164850
Uniprot IDs		Q15397	A0A024R849 Q63ZY2 Q99527
PDB IDs		4WZR 4WZW
Enriched GO Terms of Interacting Partners?
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