G3BP2 and PHACTR2

Data Source:
BioGRID (genetic interference)

		G3BP2	PHACTR2
Description		G3BP stress granule assembly factor 2	phosphatase and actin regulator 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex	Plasma Membrane Platelet Alpha Granule Membrane
	Molecular Function	RNA Binding MRNA Binding Protein Binding Signaling Receptor Complex Adaptor Activity	Actin Binding Protein Phosphatase Inhibitor Activity Protein Binding
	Biological Process	Cytoplasmic Sequestering Of NF-kappaB Ras Protein Signal Transduction Viral Process Stress Granule Assembly Innate Immune Response MRNA Transport Protein Homooligomerization Positive Regulation Of Stress Granule Assembly	Platelet Degranulation Actin Cytoskeleton Organization Negative Regulation Of Phosphoprotein Phosphatase Activity
Pathways			Platelet degranulation
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Subjective response to lithium treatment in bipolar disorder ( 26503763) Testicular germ cell tumor ( 28604728)	3-month functional outcome in non-lacunar ischaemic stroke (modified Rankin score) ( 30796134) Erectile dysfunction in type 1 diabetes ( 22704111) Inflammatory bowel disease ( 23128233) Lung Cancer (DNA repair capacity) ( 23108145) Obesity-related traits ( 23251661) Perceived sweetness of sucrose ( 31005972)
Interacting Genes		60 interacting genes: MDM2 MIR1-1 MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR128-2 MIR138-2 MIR140 MIR141 MIR145 MIR155 MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR19A MIR19B1 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR363 MIR429 MIR7-1 MIR7-2 MIR7-3 MIR92A1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NFKB1 NFKBIA PIN1 USP10 ZNF618
Entrez ID		9908	9749
HPRD ID		06570	16378
Ensembl ID		ENSG00000138757	ENSG00000112419
Uniprot IDs		A0A024RDB2 A0A024RDE5 Q9UN86	O75167
PDB IDs		5DRV
Enriched GO Terms of Interacting Partners?
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