SCRN1 and NPC2

Data Source:
BioGRID (affinity chromatography technology)

		SCRN1	NPC2
Description		secernin 1	NPC intracellular cholesterol transporter 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Membrane	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Molecular_function Protein Binding Dipeptidase Activity Cysteine-type Exopeptidase Activity	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity
	Biological Process	Proteolysis Exocytosis	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Sterol Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Neutrophil Degranulation Glycolipid Transport Intermembrane Lipid Transfer
Pathways			Neutrophil degranulation LDL clearance
Drugs
Diseases			Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Obesity-related traits ( 23251661) Psoriasis ( 25854761)	Advanced glycation end-product levels ( 26915486) Blood protein levels ( 29875488) Intraocular pressure ( 31959993) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: GORASP1 HGS ZNF25	9 interacting genes: BARD1 BRCA1 DHDDS ECT2 ERRFI1 LIG4 PAXIP1 TRIM14 USP4
Entrez ID		9805	10577
HPRD ID		15304	03008
Ensembl ID		ENSG00000136193	ENSG00000119655
Uniprot IDs		A0A024RA21 A0A090N7T9 Q12765	A0A024R6C0 P61916
PDB IDs			5KWY 6W5V
Enriched GO Terms of Interacting Partners?
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