DHX38 and NOL3

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)
HPRD (in vitro, in vivo)

		DHX38	NOL3
Description		DEAH-box helicase 38	nucleolar protein 3
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GO Annotations	Cellular Component	Intracellular Anatomical Structure Nucleus Nucleoplasm Spliceosomal Complex Membrane Catalytic Step 2 Spliceosome	Nucleolus Mitochondrion Cytosol Membrane Sarcoplasmic Reticulum
	Molecular Function	RNA Binding RNA Helicase Activity Protein Binding ATP Binding	RNA Binding Death Receptor Binding Calcium Ion Binding Protein Binding Death Effector Domain Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Caspase Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing	Response To Hypoxia Blood Vessel Remodeling Response To Ischemia MRNA Splice Site Selection RNA Splicing Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Muscle Atrophy Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Injury Involved In Regulation Of Muscle Adaptation Negative Regulation Of Apoptotic Process Protein Complex Oligomerization Negative Regulation Of Necrotic Cell Death Negative Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood protein levels ( 28240269 23696881) Cholesterol, total ( 25961943 20686565) Coronary artery disease ( 29212778) Depression ( 29700475) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) LDL cholesterol ( 25961943 20686565) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 22916037) Red blood cell count ( 32888494) Serum metabolite levels (CMS) ( 31636271) Urate levels ( 31578528)
Interacting Genes		8 interacting genes: CDC40 CSNK2A1 MFAP1 PPP4C SNRNP200 TERF2IP U2AF1 WBP4	16 interacting genes: BAX CASP2 CASP8 CSNK2A1 ETNK2 FADD NIF3L1 POT1 SIRPA SRSF9 TERF1 TERF2IP TFPT TINF2 UBQLN2 VASP
Entrez ID		9785	8996
HPRD ID		05720	05572
Ensembl ID		ENSG00000140829	ENSG00000140939
Uniprot IDs		Q92620	O60936 Q5TZN6
PDB IDs		5YZG 6ZYM 7A5P	4UZ0
Enriched GO Terms of Interacting Partners?
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