ZNF536 and TSHZ3

Data Source:
BioGRID (proximity labelling technology)

		ZNF536	TSHZ3
Description		zinc finger protein 536	teashirt zinc finger homeobox 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Nucleoplasm Plasma Membrane Growth Cone
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Retinoic Acid-responsive Element Binding Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Negative Regulation Of Neuron Differentiation Negative Regulation Of Retinoic Acid Receptor Signaling Pathway	Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Age-related hearing impairment ( 24939585) Atorvastatin-induced myopathy ( 31220337) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Cerebrospinal P-tau181p levels ( 28247064) Chin dimples ( 27182965) Chronotype ( 30696823) Falling risk ( 32999390) General risk tolerance (MTAG) ( 30643258) Major depressive disorder ( 27479909) Myocardial infarction in hypertension (calcium channel blocker interaction) ( 26516778) Myopia (pathological) ( 23049088) Obesity-related traits ( 23251661) Remission after SSRI treatment in major depression ( 30034349) Schizophrenia ( 28991256 25056061 29483656 30285260) Select biomarker traits ( 17903293) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699) Waist-to-hip ratio adjusted for body mass index ( 27195708)	Adventurousness ( 30643258) Chronotype ( 30696823) Cognitive performance ( 19734545) Corneal astigmatism ( 30306274) Diastolic blood pressure ( 27841878) Falling risk ( 32999390) FEV1 ( 30804560) Fractional exhaled nitric oxide (childhood) ( 24315451) General risk tolerance (MTAG) ( 30643258) Lung function (FEV1/FVC) ( 30061609 30804560) Peak expiratory flow ( 30804560) Photic sneeze reflex ( 27182965) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Post bronchodilator FEV1 in COPD ( 26634245) Refractive error ( 32231278) Systemising ( 31508503) Systolic blood pressure ( 27841878) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes			30 interacting genes: ANKRA2 APBB1 APEX2 CCHCR1 CEP63 CEP70 COG6 CTBP1 CTBP2 GOLGA2 HSF2BP KASH5 KRT31 KRT40 LRRC73 MAD1L1 MRPL28 MTUS2 PIBF1 RINT1 ROPN1 SPAG5 TAX1BP1 TEPSIN TFIP11 TRAF2 TRIM23 TRIM27 TRIM54 TSC1
Entrez ID		9745	57616
HPRD ID		15825	18351
Ensembl ID		ENSG00000198597	ENSG00000121297
Uniprot IDs		O15090	Q63HK5
PDB IDs			2DMI
Enriched GO Terms of Interacting Partners?
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