PRORP and SRP54

Data Source:
BioGRID (affinity chromatography technology)

		PRORP	SRP54
Description		protein only RNase P catalytic subunit	signal recognition particle 54
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Mitochondrial Ribonuclease P Complex	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Nuclear Speck
	Molecular Function	Ribonuclease P Activity Metal Ion Binding	RNA Binding GTPase Activity Protein Binding GTP Binding 7S RNA Binding GDP Binding Endoplasmic Reticulum Signal Peptide Binding Ribonucleoprotein Complex Binding
	Biological Process	TRNA 5'-leader Removal Mitochondrial TRNA Methylation RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Mitochondrial TRNA Processing Mitochondrial TRNA 5'-end Processing	SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Neutrophil Chemotaxis Granulocyte Differentiation Exocrine Pancreas Development Protein Targeting To ER
Pathways		tRNA processing in the mitochondrion tRNA modification in the mitochondrion rRNA processing in the mitochondrion	SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS			Heel bone mineral density ( 30598549) Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes			2 interacting genes: RNPS1 SRP19
Entrez ID		9692	6729
HPRD ID		18711	05330
Ensembl ID		ENSG00000100890	ENSG00000100883
Uniprot IDs		O15091	P61011
PDB IDs		4ROU 4XGL 4XGM	1MFQ 1QB2 5L3Q 6Y2Z 6Y30 6Y31 6Y32
Enriched GO Terms of Interacting Partners?
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