TTI1 and CEP250

Data Source:
BioGRID (biochemical)

		TTI1	CEP250
Description		TELO2 interacting protein 1	centrosomal protein 250
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm TORC1 Complex TORC2 Complex ASTRA Complex	Photoreceptor Outer Segment Photoreceptor Inner Segment Centrosome Centriole Microtubule Organizing Center Cytosol Protein-containing Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Protein C-terminus Binding Protein Kinase Binding Protein Domain Specific Binding
	Biological Process	Regulation Of TOR Signaling	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Localization Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Protein Localization To Organelle Detection Of Light Stimulus Involved In Visual Perception Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Protein Localization To Centrosome Non-motile Cilium Assembly
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Brain morphology (MOSTest) ( 32665545) Height ( 25429064 18391951) Refractive error ( 32231278) Ulcerative colitis ( 23128233) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		2 interacting genes: RXFP4 SUMO2	6 interacting genes: APP ATF7IP KAT2B NEK2 PLEKHA5 YWHAG
Entrez ID		9675	11190
HPRD ID		13799	09877
Ensembl ID		ENSG00000101407	ENSG00000126001
Uniprot IDs		O43156	Q9BV73
PDB IDs			6OQA
Enriched GO Terms of Interacting Partners?
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