ABCG1 and B3GALT5

Data Source:
BioGRID (enzymatic study)

		ABCG1	B3GALT5
Description		ATP binding cassette subfamily G member 1	beta-1,3-galactosyltransferase 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Mitochondrion Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Recycling Endosome	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Integral Component Of Membrane
	Molecular Function	Protein Binding ATP Binding Phospholipid Binding Cholesterol Binding ATPase Activity Toxin Transmembrane Transporter Activity ABC-type Sterol Transporter Activity Protein Homodimerization Activity ADP Binding Protein Heterodimerization Activity Phosphatidylcholine Floppase Activity Cholesterol Transfer Activity Floppase Activity	Protein Binding Acetylglucosaminyltransferase Activity Acetylgalactosaminyltransferase Activity UDP-galactose:beta-N-acetylglucosamine Beta-1,3-galactosyltransferase Activity N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity
	Biological Process	Cholesterol Metabolic Process Response To Organic Substance Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Storage Intracellular Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Response To Lipid Lipid Translocation Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Glycoprotein Transport Cholesterol Homeostasis Amyloid Precursor Protein Catabolic Process Reverse Cholesterol Transport Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Protein Secretion Transmembrane Transport Phospholipid Homeostasis Intermembrane Lipid Transfer Toxin Transport Positive Regulation Of Amyloid-beta Formation	Protein Glycosylation Poly-N-acetyllactosamine Biosynthetic Process
Pathways		ABC transporters in lipid homeostasis HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Lewis blood group biosynthesis
Drugs		ATP
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Eating disorder in bipolar disorder ( 26433762) Gout ( 22179738) HDL cholesterol levels ( 32203549) Idiopathic osteonecrosis of the femoral head ( 28000841) Neuritic plaque ( 25188341)	Alcohol dependence ( 26365420) Corneal astigmatism ( 29422769) Metabolite levels ( 23823483) Obsessive-compulsive symptoms ( 26859814) Suicide risk ( 21041247)
Interacting Genes		2 interacting genes: ABCG4 AQP6	3 interacting genes: CLEC2D DEFB103A DEFB103B
Entrez ID		9619	10317
HPRD ID		04355	06818
Ensembl ID		ENSG00000160179	ENSG00000183778
Uniprot IDs		P45844	A0A0A0MS93 Q9Y2C3
PDB IDs
Enriched GO Terms of Interacting Partners?
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