CD44 and SRD5A1

Data Source:
BioGRID (genetic interference)

		CD44	SRD5A1
Description		CD44 molecule (Indian blood group)	steroid 5 alpha-reductase 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Microvillus Focal Adhesion Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome	Endoplasmic Reticulum Membrane Integral Component Of Membrane Neuronal Cell Body Myelin Sheath Perinuclear Region Of Cytoplasm Cell Body Fiber
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Electron Transfer Activity Oxidoreductase Activity Amide Binding Cholestenone 5-alpha-reductase Activity NADPH Binding
	Biological Process	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Hyaluronan Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neutrophil Degranulation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Cartilage Development Interferon-gamma-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis	Urogenital System Development Liver Development Steroid Biosynthetic Process Androgen Biosynthetic Process Androgen Catabolic Process Sex Determination Male Gonad Development Cellular Response To Starvation Response To Muscle Activity Diterpenoid Metabolic Process Spinal Cord Development Hippocampus Development Thalamus Development Hypothalamus Development Pituitary Gland Development Cerebral Cortex Development Electron Transport Chain Cell Differentiation Male Genitalia Development Female Genitalia Development Response To Follicle-stimulating Hormone Cellular Response To Insulin Stimulus Serotonin Metabolic Process Progesterone Metabolic Process Response To Drug Circadian Sleep/wake Cycle, REM Sleep Response To Estrogen Bone Development Response To Growth Hormone Response To Fungicide Cellular Response To CAMP Cellular Response To Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Testosterone Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Epinephrine Stimulus
Pathways		Degradation of the extracellular matrix Cell surface interactions at the vascular wall Integrin cell surface interactions Hyaluronan uptake and degradation Neutrophil degranulation Interferon gamma signaling	Androgen biosynthesis
Drugs		Bivatuzumab Hyaluronic acid	Levonorgestrel Spironolactone Dutasteride Finasteride Norgestrel
Diseases		Gastric cancer
GWAS		Bone mineral density (hip) ( 30172743) Glycemic traits (pleiotropy) ( 31021400) Intake of sweets ( 31005972) Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 27399966 23273568 26502338 28714469) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Uterine fibroids ( 31649266) Vitiligo ( 27723757 22561518)	Response to amphetamines ( 22952603) Visceral fat ( 22589738)
Interacting Genes		61 interacting genes: ABCB5 AKT1 ANK1 ARHGEF1 ARHGEF12 ARNT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 EPHA2 ERBB2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK MADCAM1 MAP2K3 MAP2K5 MDM4 MET MMP1 MMP7 MMP9 MSN NF2 PDGFRA PKN1 RAF1 SELE SPP1 SRC SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL
Entrez ID		960	6715
HPRD ID		00115	01699
Ensembl ID		ENSG00000026508	ENSG00000145545
Uniprot IDs		P16070	B7Z4D8 P18405
PDB IDs		1POZ 1UUH 2I83 4PZ3 4PZ4 6TXS
Enriched GO Terms of Interacting Partners?
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