APBA3 and GPX4

Data Source:
BioGRID (affinity chromatography technology)

		APBA3	GPX4
Description		amyloid beta precursor protein binding family A member 3	glutathione peroxidase 4
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Dendritic Spine Perinuclear Region Of Cytoplasm	Nucleus Mitochondrion Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Enzyme Inhibitor Activity Protein Binding Enzyme Binding	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Identical Protein Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity
	Biological Process	In Utero Embryonic Development Chemical Synaptic Transmission Regulation Of Gene Expression Protein Transport Negative Regulation Of Catalytic Activity	Phospholipid Metabolic Process Response To Oxidative Stress Multicellular Organism Development Spermatogenesis Arachidonic Acid Metabolic Process Lipoxygenase Pathway Long-chain Fatty Acid Biosynthetic Process Protein Polymerization Cellular Oxidant Detoxification Negative Regulation Of Ferroptosis
Pathways		Neurexins and neuroligins	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives
Drugs			Glutathione Glutathione Glutathione disulfide
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 31174203) Crohn's disease ( 28067908 21102463 23128233) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 28067908) Keratinocyte cancer (MTAG) ( 31174203) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		8 interacting genes: APP ARF3 ARF4 AZI2 BCR EGFR TANK TBKBP1	3 interacting genes: MAPK13 PARK7 PRDX6
Entrez ID		9546	2879
HPRD ID		05038	11819
Ensembl ID		ENSG00000011132	ENSG00000167468
Uniprot IDs		O96018	P36969 Q6PI42
PDB IDs		2YT7 2YT8 5UWS	2GS3 2OBI 5H5Q 5H5R 5H5S 6ELW 6HKQ 6HN3
Enriched GO Terms of Interacting Partners?
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