GDF15 and BORCS8-MEF2B

Data Source:
BioGRID (proximity labelling technology)

		GDF15	BORCS8-MEF2B
Description		growth differentiation factor 15	BORCS8-MEF2B readthrough
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Cell Junction
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity BMP Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Activation Of MAPK Activity Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion	Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Myogenesis
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Severity of nausea and vomiting of pregnancy ( 29563502)	Height ( 28552196)
Interacting Genes		7 interacting genes: CBX3 HOXA1 KRTAP12-2 MAPK14 MDFI NLGN3 TACC3	9 interacting genes: AGR2 CABIN1 CTAG1A CTAG1B HDAC4 MESD TEAD1 TEKT4 TEX11
Entrez ID		9518	4207
HPRD ID		05608	02808
Ensembl ID		ENSG00000130513	ENSG00000213999
Uniprot IDs		Q99988	A0A024R7N0 Q02080
PDB IDs		5VT2 5VZ3 5VZ4 6Q2J	1N6J 1TQE 6BYY 6BZ1 6C9L 6WC2 6WC5
Enriched GO Terms of Interacting Partners?
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