GDF15 and MAST3

Data Source:
BioGRID (proximity labelling technology)

		GDF15	MAST3
Description		growth differentiation factor 15	microtubule associated serine/threonine kinase 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity BMP Receptor Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Activation Of MAPK Activity Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion	Cytoskeleton Organization Peptidyl-serine Phosphorylation Intracellular Signal Transduction
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Severity of nausea and vomiting of pregnancy ( 29563502)	Adult body size ( 32376654) Body fat mass ( 28552196) Eosinophil percentage of white cells ( 32888494) Glycine levels ( 30837465) Mental health study participation (completed survey) ( 31263887) Number of sexual partners ( 30643258) Red cell distribution width ( 32888494) Urate levels ( 31578528)
Interacting Genes		7 interacting genes: CBX3 HOXA1 KRTAP12-2 MAPK14 MDFI NLGN3 TACC3	2 interacting genes: CNTNAP4 PTEN
Entrez ID		9518	23031
HPRD ID		05608	19403
Ensembl ID		ENSG00000130513	ENSG00000099308
Uniprot IDs		Q99988	O60307
PDB IDs		5VT2 5VZ3 5VZ4 6Q2J	1V9V 3KHF
Enriched GO Terms of Interacting Partners?
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