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PIGB and SMAD6
Data Source:
BioGRID
(proximity labelling technology)
PIGB
SMAD6
Description
phosphatidylinositol glycan anchor biosynthesis class B
SMAD family member 6
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Nuclear Body
Protein-containing Complex
Heteromeric SMAD Protein Complex
Molecular Function
Alpha-1,2-mannosyltransferase Activity
Mannosyltransferase Activity
Glycolipid Mannosyltransferase Activity
Transcription Regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Identical Protein Binding
Metal Ion Binding
Co-SMAD Binding
I-SMAD Binding
R-SMAD Binding
Type I Activin Receptor Binding
Transcription Regulator Inhibitor Activity
Biological Process
GPI Anchor Biosynthetic Process
Preassembly Of GPI Anchor In ER Membrane
Mannosylation
Ureteric Bud Development
Outflow Tract Septum Morphogenesis
Aortic Valve Morphogenesis
Mitral Valve Morphogenesis
Pulmonary Valve Morphogenesis
Ventricular Septum Development
Regulation Of Transcription By RNA Polymerase II
Immune Response
Transforming Growth Factor Beta Receptor Signaling Pathway
Zygotic Specification Of Dorsal/ventral Axis
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Negative Regulation Of SMAD Protein Complex Assembly
Cell Differentiation
Negative Regulation Of Ossification
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Cell-substrate Adhesion
Response To Lipopolysaccharide
Response To Laminar Fluid Shear Stress
Aorta Development
Negative Regulation Of Apoptotic Process
Response To Estrogen
Fat Cell Differentiation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation
SMAD Protein Signal Transduction
Coronary Vasculature Development
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways
Synthesis of glycosylphosphatidylinositol (GPI)
Signaling by BMP
RUNX2 regulates bone development
Drugs
Diseases
GWAS
Asthma (
31959851
29273806
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Carpal tunnel syndrome (
30833571
)
Dental caries (decayed and filled deciduous teeth) (
31533690
)
Height (
31562340
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
Lung cancer (smoking interaction) (
24658283
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Refractive error (
32231278
)
Severe aortic features in Marfan syndrome (
30087447
)
Subcutaneous adipose tissue (
22589738
)
Waist-hip ratio (
25673412
)
Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist-to-hip ratio adjusted for body mass index (
25673412
)
Interacting Genes
17 interacting genes:
BMPR1B
CHRM5
HOXC8
MAP3K7
MAPK6
RNF111
RPS6KA5
RUNX2
SMAD1
SMAD7
SMURF1
SMURF2
STAMBP
STRAP
TAB1
TGFBR1
TOB1
Entrez ID
9488
4091
HPRD ID
04988
04240
Ensembl ID
ENSG00000069943
ENSG00000137834
Uniprot IDs
Q92521
O43541
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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