CD80 and MRPL3

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		CD80	MRPL3
Description		CD80 molecule	mitochondrial ribosomal protein L3
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Protein Complex Involved In Cell Adhesion	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity	RNA Binding Structural Constituent Of Ribosome
	Biological Process	Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway T Cell Costimulation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-2 Production Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide	Translation Mitochondrial Translational Elongation Mitochondrial Translational Termination
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs		Abatacept Galiximab Belatacept
Diseases
GWAS		Asthma ( 32296059) Autoimmune thyroid disease ( 32581359) Carotid plaque burden ( 28282560) Celiac disease ( 20190752) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lobular breast cancer (menopausal hormone therapy interaction) ( 24080446) Primary biliary cholangitis ( 28425483 23000144 21399635 26394269 28062665) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 23273568 25862617) Systemic sclerosis ( 31672989) Vitiligo ( 27723757 22561518)	Body mass index ( 26426971)
Interacting Genes		5 interacting genes: CD274 CD28 CD86 CTLA4 NGFR	2 interacting genes: APP ERCC6
Entrez ID		941	11222
HPRD ID		00202	06175
Ensembl ID		ENSG00000121594	ENSG00000114686
Uniprot IDs		A0N0P2 P33681	P09001
PDB IDs		1DR9 1I8L	3J7Y 3J9M 5OOL 5OOM 6I9R 6NU2 6NU3 6VLZ 6VMI 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG
Enriched GO Terms of Interacting Partners?
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