SOCS6 and PITRM1

Data Source:
BioGRID (genetic interference)

		SOCS6	PITRM1
Description		suppressor of cytokine signaling 6	pitrilysin metallopeptidase 1
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GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Metalloendopeptidase Activity Enzyme Activator Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Defense Response Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Phosphatidylinositol Phosphorylation Negative Regulation Of T Cell Activation	Proteolysis Protein Targeting To Mitochondrion Protein Processing Regulation Of Catalytic Activity
Pathways		Regulation of KIT signaling Neddylation Negative regulation of FLT3	Mitochondrial protein import
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) Night sleep phenotypes ( 27126917) Systemic lupus erythematosus ( 18204098) Type 2 diabetes ( 29621232)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Metabolite levels ( 23823483) Scalp hair shape ( 26926045)
Interacting Genes		39 interacting genes: ACVR1 AMOT APPL1 AR BMPR1B C1orf109 CLNK CRK DAB1 EFEMP1 EGFR ELOB ELOC ERBB2 ERBB3 ERBB4 FRS3 GAB1 INSR IRS2 IRS4 KDM1A KIT LNX1 MET PIK3R1 PIK3R2 PIK3R3 RBCK1 RELA SMURF2 TGFBR1 TUBA1A TUBB4B TXK UBE2D2 UBE2I WDR89 ZMIZ2
Entrez ID		9306	10531
HPRD ID		05491	07142
Ensembl ID		ENSG00000170677	ENSG00000107959
Uniprot IDs		A0A024R379 O14544	Q5JRX3
PDB IDs		2VIF	4L3T 4NGE 4RPU
Enriched GO Terms of Interacting Partners?
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