CD19 and RASGRP1

Data Source:
HPRD (in vivo, in vitro)

		CD19	RASGRP1
Description		CD19 molecule	RAS guanyl releasing protein 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Protein-containing Complex Membrane Raft Extracellular Exosome	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Zinc Ion Binding Lipid Binding Diacylglycerol Binding Phosphatidylcholine Binding Identical Protein Binding
	Biological Process	B-1 B Cell Differentiation B Cell Proliferation Involved In Immune Response Immunoglobulin Mediated Immune Response Regulation Of Complement Activation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Regulation Of B Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Kinase B Signaling	MAPK Cascade Positive Regulation Of Protein Phosphorylation Signal Transduction Ras Protein Signal Transduction Natural Killer Cell Activation Cell Differentiation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Proliferation B Cell Proliferation T Cell Activation B Cell Activation Positive Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of JNK Cascade Positive Regulation Of Ras Protein Signal Transduction Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Regulation Of Phospholipase C Activity Regulation Of P38MAPK Cascade
Pathways		PIP3 activates AKT signaling Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Regulation of Complement cascade Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Effects of PIP2 hydrolysis Activation of RAS in B cells Activation of RAS in B cells FCERI mediated NF-kB activation Integrin signaling Rap1 signalling RAF/MAP kinase cascade
Drugs		Coltuximab ravtansine Blinatumomab Inebilizumab Tisagenlecleucel Axicabtagene ciloleucel Tafasitamab Brexucabtagene autoleucel
Diseases		Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Bipolar disorder ( 18711365) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Crohn's disease ( 28067908 23128233) Estimated glomerular filtration rate ( 30604766) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Multiple sclerosis ( 24076602) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Psychosis (atypical) ( 24132900) Rheumatoid arthritis ( 30423114 30572963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 21829393 25751624 18840781) Type 2 diabetes ( 30297969 28254843 22961080 32499647 30718926)
Interacting Genes		21 interacting genes: ABL1 BTK CBL CD22 CD79A CD79B CD81 CD82 CD9 CR2 ECT2 FYN GRB2 LYN MAPK1 PIK3R1 PLCG2 SOS1 SYK VAV1 VAV2	2 interacting genes: DGKZ HRAS
Entrez ID		930	10125
HPRD ID		00113	04909
Ensembl ID		ENSG00000177455	ENSG00000172575
Uniprot IDs		P15391	B2RA89 O95267
PDB IDs		6AL5	4L9M 4L9U
Enriched GO Terms of Interacting Partners?
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