MARS2 and TYW5

Data Source:
BioGRID (biochemical)

		MARS2	TYW5
Description		methionyl-tRNA synthetase 2, mitochondrial	tRNA-yW synthesizing protein 5
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Matrix	Cytoplasm
	Molecular Function	Methionine-tRNA Ligase Activity ATP Binding	TRNA Binding Iron Ion Binding 2-oxoglutarate-dependent Dioxygenase Activity Protein Homodimerization Activity TRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase Activity
	Biological Process	TRNA Aminoacylation For Protein Translation Methionyl-tRNA Aminoacylation	TRNA Modification Wybutosine Biosynthetic Process
Pathways		Mitochondrial tRNA aminoacylation	Synthesis of wybutosine at G37 of tRNA(Phe)
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Idiopathic dilated cardiomyopathy ( 29495422) Morning person ( 30696823) Schizophrenia ( 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) QT interval (sulfonylurea treatment interaction) ( 27958378) Schizophrenia ( 28991256 29483656 23974872) Sleep duration ( 30846698) Type 2 diabetes ( 25760438)
Interacting Genes		1 interacting genes: APP
Entrez ID		92935	129450
HPRD ID		14363	08232
Ensembl ID		ENSG00000247626	ENSG00000162971
Uniprot IDs		Q96GW9	A2RUC4
PDB IDs			3AL5 3AL6
Enriched GO Terms of Interacting Partners?
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