MRRF and CDK5RAP2

Data Source:
BioGRID (genetic interference)

		MRRF	CDK5RAP2
Description		mitochondrial ribosome recycling factor	CDK5 regulatory subunit associated protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Pericentriolar Material Spindle Pole Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Gamma-tubulin Ring Complex Cell Junction Microtubule Plus-end Perinuclear Region Of Cytoplasm Extracellular Exosome Mitotic Spindle Pole
	Molecular Function	Protein Binding Ribosomal Large Subunit Binding	Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Gamma-tubulin Binding
	Biological Process	Translation Ribosome Disassembly Mitochondrial Translational Termination	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Microtubule Bundle Formation Chromosome Segregation Centrosome Cycle Centriole Replication Brain Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Neurogenesis Microtubule Organizing Center Organization Positive Regulation Of Microtubule Polymerization Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Centriole Replication Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Ciliary Basal Body-plasma Membrane Docking
Pathways		Mitochondrial translation termination	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases			Primary microcephaly (MCPH)
GWAS			Asthma ( 27611488) Height ( 28552196) Photic sneeze reflex ( 27182965) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 24782177)
Interacting Genes		10 interacting genes: AGTRAP APP BANP CMTM5 FAM9B FHL3 KRT40 SYP WIPI2 ZNF408	25 interacting genes: ABCA2 CDK5 CDK5R1 CLIP4 CRMP1 EEF1G ERG28 FBXO25 HAP1 KAT5 LUC7L2 MAGEH1 MAPRE1 NEFL PCBD1 PTN RBM48 REPS2 SENP2 STARD9 STK36 TBC1D4 TRIM37 TSNAX ZPR1
Entrez ID		92399	55755
HPRD ID		06856	09740
Ensembl ID		ENSG00000148187	ENSG00000136861
Uniprot IDs		Q96E11	A0A0A0MRG9 B3KVI2 B9EG74 Q7Z3M0 Q96SN8
PDB IDs		6NU2 6ZS9
Enriched GO Terms of Interacting Partners?
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