INTS4 and FOLR1

Data Source:
BioGRID (affinity chromatography technology)

		INTS4	FOLR1
Description		integrator complex subunit 4	folate receptor alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Integrator Complex	Golgi Membrane Nucleus Endosome Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Clathrin-coated Vesicle Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Folic Acid Binding Signaling Receptor Activity Methotrexate Binding Folic Acid Receptor Activity
	Biological Process	SnRNA Processing SnRNA Transcription By RNA Polymerase II	Heart Looping Neural Crest Cell Migration Involved In Heart Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Cell Adhesion Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Folic Acid Transport Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Regeneration Sperm-egg Recognition Folic Acid Metabolic Process COPII Vesicle Coating Regulation Of Canonical Wnt Signaling Pathway Pharyngeal Arch Artery Morphogenesis Anterior Neural Tube Closure Cellular Response To Folic Acid Folate Import Across Plasma Membrane
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes	COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport
Drugs			Folic acid Vintafolide Farletuzumab
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Platelet count ( 32888494) Tourette syndrome ( 30818990)
Interacting Genes		7 interacting genes: HGS KIAA0513 LHX3 MEIS3 PYGM USHBP1 ZMIZ2	6 interacting genes: CUL3 IRAK3 LTB4R2 LYN NCAPH2 SLC35F6
Entrez ID		92105	2348
HPRD ID		12386	00638
Ensembl ID		ENSG00000149262	ENSG00000110195
Uniprot IDs		Q96HW7	A0A024R5H1 P15328
PDB IDs			4KM6 4KM7 4KMX 4LRH 5IZQ
Enriched GO Terms of Interacting Partners?
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