EOLA1 and NPC2

Data Source:
HPRD (in vivo, in vitro)

		EOLA1	NPC2
Description		endothelium and lymphocyte associated ASCH domain 1	NPC intracellular cholesterol transporter 2
Image
GO Annotations	Cellular Component		Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity
	Biological Process	Regulation Of Gene Expression Regulation Of Interleukin-6 Production	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Sterol Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Neutrophil Degranulation Glycolipid Transport Intermembrane Lipid Transfer
Pathways			Neutrophil degranulation LDL clearance
Drugs
Diseases			Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS			Advanced glycation end-product levels ( 26915486) Blood protein levels ( 29875488) Intraocular pressure ( 31959993) Refractive error ( 32231278)
Interacting Genes		1 interacting genes: MT2A	9 interacting genes: BARD1 BRCA1 DHDDS ECT2 ERRFI1 LIG4 PAXIP1 TRIM14 USP4
Entrez ID		91966	10577
HPRD ID		06625	03008
Ensembl ID		ENSG00000197620	ENSG00000119655
Uniprot IDs		Q8TE69	A0A024R6C0 P61916
PDB IDs		5Y7D	5KWY 6W5V
Enriched GO Terms of Interacting Partners?
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