SLFN11 and CSF3

Data Source:
HPRD (in vivo)

		SLFN11	CSF3
Description		schlafen family member 11	colony stimulating factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Site Of DNA Damage	Extracellular Region Extracellular Space
	Molecular Function	TRNA Binding Helicase Activity Protein Binding ATP Binding ATPase Activity	Cytokine Activity Granulocyte Colony-stimulating Factor Receptor Binding Growth Factor Activity Enzyme Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Replication Positive Regulation Of Cell Death Replication Fork Arrest Defense Response To Virus Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Immune Response Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cytokine-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Granulocyte Differentiation Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Response To Ethanol Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Negative Regulation Of Neuron Death Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways			Other interleukin signaling Interleukin-10 signaling
Drugs
Diseases
GWAS		Barrett's esophagus x pack-years of smoking exposure interaction ( 29551738)	Asthma ( 31619474) Bipolar disorder ( 31043756) Composite immunoglobulin trait (IgA x IgG) ( 28628107) Creatine kinase levels ( 29403010) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mitochondrial DNA copy number ( 30704525) Myeloid white cell count ( 27863252) Neutrophil count ( 25096241 20172861 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Rheumatoid arthritis ( 30423114 24390342) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 29403010 32888494 20139978 27863252 21738480 28158719) White blood cell count (neutrophil) ( 28158719) White blood cell types ( 21738478)
Interacting Genes			4 interacting genes: CSF3R ELANE PARVG TBX3
Entrez ID		91607	1440
HPRD ID		08178	00736
Ensembl ID		ENSG00000172716	ENSG00000108342
Uniprot IDs		Q7Z7L1	P09919 Q6FH65 Q8N4W3
PDB IDs			1CD9 1GNC 1PGR 1RHG 2D9Q 5GW9 5ZO6
Enriched GO Terms of Interacting Partners?
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