SART1 and PLAT

Data Source:
BioGRID (affinity chromatography technology)

		SART1	PLAT
Description		spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP	plasminogen activator, tissue type
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Extracellular Region Extracellular Space Cytoplasm Cell Surface Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Phosphoprotein Binding
	Biological Process	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Maturation Of 5S RRNA MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Cytotoxic T Cell Differentiation	Cellular Protein Modification Process Proteolysis Blood Coagulation Smooth Muscle Cell Migration Plasminogen Activation Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway
Pathways		mRNA Splicing - Major Pathway	Signaling by PDGF Dissolution of Fibrin Clot
Drugs			Aminocaproic acid Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa
Diseases
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)
Interacting Genes		13 interacting genes: APP CHERP HSF2BP IGHE MFAP1 SNW1 SRPK2 SRSF4 SUMO2 UBE2I UBL5 WBP4 ZCCHC10	27 interacting genes: ANXA2 APP CALR CKAP4 CLEC3B F10 FGA FN1 GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG SERPINA5 SERPINE1 SERPING1 SERPINI1 SPARC VDAC1
Entrez ID		9092	5327
HPRD ID		10440	01419
Ensembl ID		ENSG00000175467	ENSG00000104368
Uniprot IDs		O43290	B4DN26 P00750
PDB IDs		4PYU 5O9Z 6AHD 6QW6 6QX9	1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ
Enriched GO Terms of Interacting Partners?
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