SHF and SEMA6D

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SHF	SEMA6D
Description		Src homology 2 domain containing F	semaphorin 6D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Extracellular Space Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Phosphotyrosine Residue Binding	Semaphorin Receptor Binding Chemorepellent Activity
	Biological Process	Apoptotic Process	Neural Crest Cell Migration Axon Guidance Positive Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Smooth Muscle Cell Migration Ventricular System Development Positive Regulation Of Cell Migration Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Semaphorin-plexin Signaling Pathway
Pathways			Other semaphorin interactions
Drugs
Diseases
GWAS		Bisphosphonate-associated atypical femoral fracture ( 31006051) Initial alcohol sensitivity ( 30276832)	Adult body size ( 32376654) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Antisaccade task score ( 31596458) Attention deficit hyperactivity disorder ( 29325848) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Attention deficit hyperactivity disorder or intracranial volume (pleiotropy) ( 30818988) Attention deficit hyperactivity disorder or putamen volume (pleiotropy) ( 30818988) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Carotid plaque burden (smoking interaction) ( 24954085) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery calcification ( 23870195) Cuneus cortex volume ( 31530798) Diisocyanate-induced asthma ( 25918132) Eating disorders ( 22911880) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Hair greying ( 26926045) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28008999) Lack of perseverance ( 30718321) Lung cancer ( 28604730) Lung function (FVC) ( 30061609) Neurociticism ( 29500382) Neuroticism ( 29255261) Number of sexual partners ( 30643258) Oily fish consumption ( 32066663) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Pericalcarine cortex volume ( 31530798) Phoneme awareness ( 30741946) Pork consumption ( 32066663) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to radiotherapy in cancer (late toxicity) ( 24785509) Restless legs syndrome ( 29029846) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 28008999)
Interacting Genes		2 interacting genes: CHN2 PDGFRA	1 interacting genes: PLXNA1
Entrez ID		90525	80031
HPRD ID		14272	10221
Ensembl ID		ENSG00000138606	ENSG00000137872
Uniprot IDs		B3KTY1 B4DWP8 B4E1A9 H0YLM1	A0A185QE25 Q8NFY4
PDB IDs
Enriched GO Terms of Interacting Partners?
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