H1-10 and PLXND1

Data Source:
BioGRID (affinity chromatography technology)

		H1-10	PLXND1
Description		H1.10 linker histone	plexin D1
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GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Nucleolus	Semaphorin Receptor Complex Plasma Membrane Integral Component Of Plasma Membrane Lamellipodium Lamellipodium Membrane
	Molecular Function	Double-stranded DNA Binding RNA Binding Nucleosomal DNA Binding Cadherin Binding	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding
	Biological Process	Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Kidney Development Outflow Tract Morphogenesis Cardiac Septum Development Negative Regulation Of Cell Adhesion Positive Regulation Of Transcription Of Notch Receptor Target Synapse Assembly Regulation Of Cell Shape Regulation Of Cell Migration Positive Regulation Of Protein Binding Aorta Development Regulation Of GTPase Activity Endothelial Cell Migration Regulation Of Angiogenesis Positive Regulation Of Axonogenesis Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Coronary Vasculature Development Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Pathways			Other semaphorin interactions NOTCH3 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS			Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		3 interacting genes: CDC42 IL7R XBP1	3 interacting genes: HOXB5 MACF1 SEMA4A
Entrez ID		8971	23129
HPRD ID		04151	05046
Ensembl ID		ENSG00000184897	ENSG00000004399
Uniprot IDs		Q92522	Q9Y4D7
PDB IDs		2LSO	3H6N
Enriched GO Terms of Interacting Partners?
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