CACNA1G and MKS1

Data Source:
HPRD (in vitro)

		CACNA1G	MKS1
Description		calcium voltage-gated channel subunit alpha1 G	MKS transition zone complex subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Neuron Projection Synapse	Cytoplasm Centrosome Cytosol MKS Complex Ciliary Basal Body
	Molecular Function	Voltage-gated Sodium Channel Activity Low Voltage-gated Calcium Channel Activity Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved SA Node Cell Action Potential Scaffold Protein Binding	Protein Binding
	Biological Process	Chemical Synaptic Transmission Response To Nickel Cation Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Calcium Ion Import Calcium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Action Potential SA Node Cell Action Potential AV Node Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Signaling AV Node Cell To Bundle Of His Cell Signaling Membrane Depolarization During AV Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction	Cilium Assembly Ciliary Basal Body-plasma Membrane Docking
Pathways		NCAM1 interactions	Hedgehog 'off' state Anchoring of the basal body to the plasma membrane
Drugs		Ergocalciferol Enflurane Trimethadione Spironolactone Cinnarizine Ethosuximide Verapamil Zonisamide Nifedipine Mibefradil Flunarizine Methsuximide Cannabidiol Trimebutine Benidipine Manidipine Butamben Bioallethrin Bioallethrin Medical Cannabis Nabiximols
Diseases			Bardet-Biedl syndrome (BBS) Meckel syndrome (MKS); Meckel-Gruber syndrome
GWAS		Adventurousness ( 30643258) Alzheimer's disease (cognitive decline) ( 23535033) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) PR interval ( 32439900) Total cholesterol levels ( 30498476)	Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		2 interacting genes: RANBP9 UBQLN4	2 interacting genes: DDX24 TMEM67
Entrez ID		8913	54903
HPRD ID		04961	07900
Ensembl ID		ENSG00000006283	ENSG00000011143
Uniprot IDs		O43497	A0A0S2Z5Z2 B4DVC5 H0Y2S2 J3KSC6 Q9NXB0
PDB IDs		6KZO 6KZP
Enriched GO Terms of Interacting Partners?
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