CACNA1I and APOL1

Data Source:
BioGRID (affinity chromatography technology)

		CACNA1I	APOL1
Description		calcium voltage-gated channel subunit alpha1 I	apolipoprotein L1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Voltage-gated Calcium Channel Complex Neuron Projection	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Intrinsic Component Of Membrane Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Blood Microparticle
	Molecular Function	Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Protein Binding Low Voltage-gated Calcium Channel Activity	Chloride Channel Activity Protein Binding Lipid Binding
	Biological Process	Signal Transduction Neuronal Action Potential Flagellated Sperm Motility Sleep Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential	Lipid Transport Receptor-mediated Endocytosis Cholesterol Metabolic Process Lipoprotein Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Cytolysis By Host Of Symbiont Cells Chloride Transmembrane Transport
Pathways		NCAM1 interactions	Scavenging of heme from plasma Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Ergocalciferol Enflurane Amlodipine Spironolactone Cinnarizine Paramethadione Zonisamide Nifedipine Amiodarone Mibefradil Flunarizine Nylidrin Cannabidiol Trimebutine Benidipine Efonidipine Manidipine Butamben Bioallethrin Bioallethrin Medical Cannabis Nabiximols	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Household income (MTAG) ( 31844048) IgG glycosylation ( 23382691) Intelligence (MTAG) ( 29326435) Negative urgency ( 30718321) Refractive error ( 32231278) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Schizophrenia ( 28991256 22883433 29483656 30285260)	Blood protein levels ( 30072576 29875488) Diabetic kidney disease ( 26305897) End-stage kidney disease ( 31178898) End-stage renal disease ( 29885931) Glomerulosclerosis ( 20668430)
Interacting Genes			2 interacting genes: APOA1 CDC23
Entrez ID		8911	8542
HPRD ID		10500	04774
Ensembl ID		ENSG00000100346	ENSG00000100342
Uniprot IDs		Q9P0X4	B1AH95 O14791 Q2KHQ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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