CACNA1I and PLA2G6

Data Source:
BioGRID (affinity chromatography technology)

		CACNA1I	PLA2G6
Description		calcium voltage-gated channel subunit alpha1 I	phospholipase A2 group VI
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Voltage-gated Calcium Channel Complex Neuron Projection	Extracellular Space Mitochondrion Cytosol Plasma Membrane Integral Component Of Membrane Pseudopodium Centriolar Satellite
	Molecular Function	Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Protein Binding Low Voltage-gated Calcium Channel Activity	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Lysophospholipase Activity Phospholipase A2 Activity Protein Binding Calmodulin Binding Palmitoyl-CoA Hydrolase Activity Hydrolase Activity Identical Protein Binding Calcium-independent Phospholipase A2 Activity Phosphatidyl Phospholipase B Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine) Myristoyl-CoA Hydrolase Activity
	Biological Process	Signal Transduction Neuronal Action Potential Flagellated Sperm Motility Sleep Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential	Chemotaxis Antibacterial Humoral Response Cardiolipin Biosynthetic Process Phosphatidylcholine Catabolic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cardiolipin Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Phosphatidylethanolamine Catabolic Process Platelet Activating Factor Metabolic Process Phosphatidic Acid Metabolic Process
Pathways		NCAM1 interactions	Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PE Role of phospholipids in phagocytosis COPI-independent Golgi-to-ER retrograde traffic
Drugs		Ergocalciferol Enflurane Amlodipine Spironolactone Cinnarizine Paramethadione Zonisamide Nifedipine Amiodarone Mibefradil Flunarizine Nylidrin Cannabidiol Trimebutine Benidipine Efonidipine Manidipine Butamben Bioallethrin Bioallethrin Medical Cannabis Nabiximols	Quinacrine
Diseases			Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia Parkinson's disease (PD)
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Household income (MTAG) ( 31844048) IgG glycosylation ( 23382691) Intelligence (MTAG) ( 29326435) Negative urgency ( 30718321) Refractive error ( 32231278) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Schizophrenia ( 28991256 22883433 29483656 30285260)	Apolipoprotein A1 levels ( 32203549) Body fat percentage ( 26833246) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cutaneous nevi ( 21478494 19578365) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) Mammographic density (dense area) ( 25342443) Melanoma ( 21983787 28212542) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Percent mammographic density ( 25342443) Platelet distribution width ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Triglyceride levels ( 32203549 28334899 32154731) Triglycerides ( 24097068 20686565)
Interacting Genes			11 interacting genes: CALM1 CCDC33 CEP76 MAT2B NUP93 RCBTB2 RUSC1 SERTAD2 TRIM50 USP54 ZBTB42
Entrez ID		8911	8398
HPRD ID		10500	04675
Ensembl ID		ENSG00000100346	ENSG00000184381
Uniprot IDs		Q9P0X4	O60733
PDB IDs
Enriched GO Terms of Interacting Partners?
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