CFLAR and QPCT

Data Source:
BioGRID (proximity labelling technology)

		CFLAR	QPCT
Description		CASP8 and FADD like apoptosis regulator	glutaminyl-peptide cyclotransferase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Ripoptosome	Extracellular Region Specific Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protease Binding Death Receptor Binding Protein Binding Enzyme Activator Activity Protein-containing Complex Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Protein Binding Zinc Ion Binding Glutaminyl-peptide Cyclotransferase Activity
	Biological Process	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Development Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Skeletal Muscle Atrophy Regulation Of Skeletal Muscle Satellite Cell Proliferation Skeletal Myofibril Assembly Viral Process Cellular Response To Insulin Stimulus Response To Testosterone Wound Healing Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Skeletal Muscle Tissue Regeneration Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Necroptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Glomerular Mesangial Cell Proliferation Apoptotic Signaling Pathway Execution Phase Of Apoptosis Negative Regulation Of Myoblast Fusion Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extracellular Matrix Organization Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Cellular Protein Modification Process Peptidyl-pyroglutamic Acid Biosynthetic Process, Using Glutaminyl-peptide Cyclotransferase Protein Phosphopantetheinylation Neutrophil Degranulation
Pathways		TRAIL signaling	Neutrophil degranulation
Drugs			1-benzylimidazole N-acetylhistamine Glutamine t-butyl ester
Diseases
GWAS		Rheumatoid arthritis ( 30423114 24390342) Triptolide cytotoxicity ( 26121980)	Blood protein levels ( 30072576) Body mass index ( 28892062) Chronic lymphocytic leukemia ( 28165464 26956414 24292274) Height ( 31562340) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Schizophrenia ( 30285260 23974872)
Interacting Genes		25 interacting genes: BCL2L1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 DAXX DEDD DEDD2 FADD IKBKB MAP2K4 MAP2K7 NFKB1 PSEN2 RAF1 RIPK1 RIPK2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2 USP8	2 interacting genes: HRAS UBQLN2
Entrez ID		8837	25797
HPRD ID		04671	06140
Ensembl ID		ENSG00000003402	ENSG00000115828
Uniprot IDs		A0A024R3Y3 A0A024R3Y4 A0A336TY74 B4E361 E9PAP3 O15519 Q59F61	Q16769
PDB IDs		2N5R 3H11 3H13	1MOI 2AFM 2AFO 2AFS 2AFU 2AFW 2AFX 2AFZ 2ZED 2ZEE 2ZEF 2ZEG 2ZEH 2ZEL 2ZEM 2ZEN 2ZEO 2ZEP 3PBB 3PBE 3SI0 4YU9 4YWY 6GBX 6YI1 6YJY
Enriched GO Terms of Interacting Partners?
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