GGH and CHD7

Data Source:
BioGRID (proximity labelling technology)

		GGH	CHD7
Description		gamma-glutamyl hydrolase	chromodomain helicase DNA binding protein 7
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Vacuole Cytosol Azurophil Granule Lumen Specific Granule Lumen Melanosome Extracellular Exosome Tertiary Granule Lumen	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding Exopeptidase Activity Omega Peptidase Activity Gamma-glutamyl-peptidase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Promoter-specific Chromatin Binding
	Biological Process	Proteolysis Response To Zinc Ion Response To Insulin Response To Drug Neutrophil Degranulation Response To Ethanol Tetrahydrofolylpolyglutamate Metabolic Process	Skeletal System Development In Utero Embryonic Development Blood Vessel Remodeling Heart Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Right Ventricular Compact Myocardium Morphogenesis Chromatin Remodeling Regulation Of Transcription, DNA-templated RRNA Processing Central Nervous System Development Adult Heart Development Sensory Perception Of Sound Adult Walking Behavior Blood Circulation Response To Bacterium Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cranial Nerve Development Olfactory Nerve Development Olfactory Bulb Development T Cell Differentiation Female Genitalia Development DNA Duplex Unwinding Embryonic Hindlimb Morphogenesis Aorta Morphogenesis Atrioventricular Canal Development Positive Regulation Of Multicellular Organism Growth Olfactory Behavior Inner Ear Morphogenesis Nose Development Positive Regulation Of Transcription By RNA Polymerase II Semicircular Canal Morphogenesis Genitalia Development Regulation Of Neurogenesis Cognition Retina Development In Camera-type Eye Regulation Of Growth Hormone Secretion Limb Development Face Development Innervation Cardiac Septum Morphogenesis Epithelium Development Secondary Palate Development
Pathways		Neutrophil degranulation
Drugs
Diseases			Hypogonadotropic hypogonadism; Kallmann syndrome (KAL) CHARGE syndrome
GWAS		Blood protein levels ( 30072576 29875488)	Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Eosinophil counts ( 29403010 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 28552196) Lymphocyte percentage of white cells ( 32888494 27863252) Menopause (age at onset) ( 26414677) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Neutrophil count ( 29403010 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Pulmonary function decline ( 22424883) Refractive error ( 23396134 32231278) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic sclerosis ( 31672989) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532) White blood cell count ( 29403010 32888494 27863252)
Interacting Genes		2 interacting genes: LIG4 SGTB	2 interacting genes: CHD8 CTCF
Entrez ID		8836	55636
HPRD ID		03299	10595
Ensembl ID		ENSG00000137563	ENSG00000171316
Uniprot IDs		Q92820	Q6ZWF9 Q9P2D1
PDB IDs		1L9X	2CKC 2V0E 2V0F
Enriched GO Terms of Interacting Partners?
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