PABPC4 and NMNAT1

Data Source:
BioGRID (proximity labelling technology)

		PABPC4	NMNAT1
Description		poly(A) binding protein cytoplasmic 4	nicotinamide nucleotide adenylyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Poly(C) RNA Binding	Nicotinamide-nucleotide Adenylyltransferase Activity Nicotinate-nucleotide Adenylyltransferase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	RNA Processing RNA Catabolic Process Translation Blood Coagulation Regulation Of MRNA Stability Myeloid Cell Development	Nucleotide Biosynthetic Process NAD Biosynthetic Process Response To Wounding NAD Metabolic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic DNA Fragmentation ATP Generation From Poly-ADP-D-ribose
Pathways			Nicotinate metabolism
Drugs			Nicotinamide Mononucleotide Deamido-Nad+
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Chronic obstructive pulmonary disease ( 30804561) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coffee consumption ( 31046077) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27618448) HDL cholesterol ( 24097068 30275531 25961943 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29615537) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552) Red cell distribution width ( 32888494 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Resting heart rate ( 27798624)
Interacting Genes		15 interacting genes: CDC42 DUX4 EEF1A1 GDF9 HAP1 IL7R MED31 PHLDA1 RIF1 SETDB1 SMAD9 SREK1 SRPK2 UBC XRN1	19 interacting genes: APP BANP CCNC FLOT2 GORASP2 KPNA1 KPNA2 KPNA3 KPNA5 KPNA6 MSX1 NEK3 NFATC2IP NTRK2 PICK1 RNF4 SIK1 SIRT1 TDO2
Entrez ID		8761	64802
HPRD ID		04557	16369
Ensembl ID		ENSG00000090621	ENSG00000173614
Uniprot IDs		Q13310	A0A024R4E1 B1AN62 Q9HAN9
PDB IDs			1GZU 1KKU 1KQN 1KQO 1KR2
Enriched GO Terms of Interacting Partners?
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